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Abstract:
Transition-metal-catalyzed direct inert C-H bond functionalization has attracted much attention over the past decades. However, because of the high strain energy of the suspected palladacycle generated via C-H bond palladation, direct functionalization of a C-H bond less than a three-bond distance from a catalyst center is highly challenging. In this short review, we summarize the advances on palladium-catalyzed bridging C-H activation, in which an inert proximal C-H bond palladation is promoted by the elementary step of migratory insertion of an alkene, an alkyne or a metal carbene intermediate. 1 Introduction 2 Palladium-Catalyzed Alkene Bridging C-H Activation 2.1 Intramolecular Reactions 2.2 Intermolecular Reactions 3 Palladium-Catalyzed Alkyne Bridging C-H Activation 3.1 Intermolecular Reactions 3.2 Intramolecular Reactions 4 Palladium-Catalyzed Carbene Bridging C-H Activation 5 Conclusion and Outlook. © 2020 BMJ Publishing Group. All rights reserved.
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Source :
Synthesis (Germany)
ISSN: 0039-7881
Year: 2021
Issue: 2
Volume: 53
Page: 238-254
2 . 9 6 9
JCR@2021
2 . 2 0 0
JCR@2023
ESI HC Threshold:117
JCR Journal Grade:2
CAS Journal Grade:3
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