Propane　nonoxidative　dehydrogenation　(PDH)　is　a　promising　route　to　produce　propylene　with　the　development　of　shale　gas　exploration　technology.　Co-based　catalysts　with　low　cost　and　low　toxicity　could　activate　C-H　effectively,　but　they　suffer　from　deactivation　with　coke　formation.　In　this　work,　a　catalyst　formed　by　incorporating　highly　dispersed　Co　sites　into　a　Silicalite-1　zeolite　framework　(Co-Silicalite-1)　is　synthesized　by　a　hydrothermal　protocol　in　the　presence　of　ammonia,　which　exhibits　superior　propane　dehydrogenation　catalytic　performance　with　0.0946　mmol　C3H6·s-1·gCo-1　and　propylene　selectivity　higher　than　98.5%.　It　also　shows　outstanding　catalytic　stability　and　coking　resistance　in　a　3560　min　time-on-stream.　Combined　characterization　results　demonstrate　that　the　tetrahedrally　coordinated　Co2+　site　serves　as　the　PDH　catalytic　active　site,　which　is　stabilized　by　Si-O　units　of　the　zeolite　framework.　Incorporation　of　Co　sites　into　the　zeolite　framework　could　avoid　the　reduction　of　Co　species　to　metallic　Co.　Moreover,　the　catalytic　performance　is　improved　by　the　enhanced　propane　adsorption　and　propylene　desorption.　©　2021　American　Chemical　Society.