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author:

Wang, Rui (Wang, Rui.) [1] | Li, Xingshu (Li, Xingshu.) [2] | Yoon, Juyoung (Yoon, Juyoung.) [3]

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EI

Abstract:

Subcellular organelles are the cornerstones of cells, and destroying them will cause cell dysfunction and even death. Therefore, realizing precise organelle targeting of photosensitizers (PSs) can help reduce PS dosage, minimize side effects, avoid drug resistance, and enhance therapeutic efficacy in photodynamic therapy (PDT). Organelle-targeted PSs provide a new paradigm for the construction of the next generation of PSs and may provide implementable strategies for future precision medicine. In this Review, the recent targeting strategies of different organelles and the corresponding design principles of molecular and nanostructured PSs are summarized and discussed. The current challenges and opportunities in organelle-targeted PDT are also presented. ©

Keyword:

Cell proliferation Drug dosage Photodynamic therapy Photosensitizers

Community:

  • [ 1 ] [Wang, Rui]Department of Chemistry and Nanoscience, Ewha Womans University, Seoul; 03760, Korea, Republic of
  • [ 2 ] [Li, Xingshu]College of Chemistry, State Key Laboratory of Photocatalysis for Energy and the Environment, Fujian Provincial Key Laboratory for Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou; 350108, China
  • [ 3 ] [Yoon, Juyoung]Department of Chemistry and Nanoscience, Ewha Womans University, Seoul; 03760, Korea, Republic of

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Source :

ACS Applied Materials and Interfaces

ISSN: 1944-8244

Year: 2021

Issue: 17

Volume: 13

Page: 19543-19571

1 0 . 3 8 3

JCR@2021

8 . 5 0 0

JCR@2023

ESI HC Threshold:142

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 169

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 4

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