Unlike　the　comprehensive　development　of　tandem　multi-metallic　catalysis,　bimetallic　synergistic　catalysis　has　been　challenging　to　achieve　high　stereoselectivity　with　the　generation　of　multi-stereogenic　centers.　Herein,　an　efficient　synergistic　catalysis　for　the　diastereo-　and　enantioselective　synthesis　of　multi-substituted　tetrahydrofuran　derivatives　has　been　developed.　Under　mild　reaction　conditions,　a　series　of　target　molecules　with　three　consecutive　stereocenters　were　synthesized　by　a　palladium(0)/rhodium(III)　bimetal-catalyzed　asymmetric　decarboxylative　[3+2]-cycloaddition　of　vinylethylene　carbonates　with　α,β-unsaturated　carbonyl　compounds.　The　corresponding　adducts　were　obtained　with　moderate　to　high　yields　(67　%∼98　%)　and　excellent　stereoselectivities　(＞20　:　1　d.r.,　up　to　99　%　ee).　©　2021　Wiley-VCH　GmbH