Biomimetic　scaffolds　loaded　with　drugs　can　be　applied　in　bone　tissue　engineering.　In　this　study,　a　series　of　three-dimensional　polylactic　acid/hydroxyapatite/graphene　oxide　(PLA/HA/GO)　drug-loaded　biomimetic　composite　scaffolds　with　different　concentrations　of　aspirin　(ASA;　0-50　wt%)　was　successfully　prepared　using　the　phase　separation　technique.　ASA　addition　increased　the　scaffold　pore　size　without　destroying　the　biomimetic　structure.　The　hydrophilicity　of　a　PLA/HA/GO/ASA　drug-loaded　biomimetic　composite　scaffold　is　linked　to　the　component　and　structure　of　the　prepared　scaffold.　The　porosity　can　reach　＞85%　in　all　samples.　A　test　to　assess　the　apatite-formation　ability　confirmed　that　the　prepared　composite　scaffold　had　good　bioactivity　and　could　induce　the　formation　of　spherical　hydroxyapatites.　The　haemolysis　rate,　platelet　adhesion　andin　vitrocell　proliferation　experiments　showed　that　the　prepared　scaffold　had　good　haemocompatibility　and　cytocompatibility.　However,　ASA　addition　demonstrated　an　inhibitory　effect　on　MC3T3-E1　cells.　The　prepared　PLA/HA/GO/ASA　drug-loaded　biomimetic　composite　scaffold　revealed　good　sustained　drug-release　performance.　Hence,　different　concentrations　of　ASA　can　be　loaded　onto　the　scaffold　on　the　basis　of　therapy　requirements.　©　The　Royal　Society　of　Chemistry　and　the　Centre　National　de　la　Recherche　Scientifique　2021.