Employing　natural　cells　as　drug　carriers　has　been　a　hotspot　in　recent　years,　attributing　to　their　biocom-patibility　and　inherent　dynamic　properties.　In　the　earlier　stage,　cells　were　mainly　used　as　vehicles　by　vir-tue　of　their　lipid-delimited　compartmentalized　structures　and　native　membrane　proteins.　The　scope　emphasis　was　＇what　cell　displays＇　instead　of　＇how　cell　changes＇.　More　recently,　the　dynamic　behaviours,　such　as　changes　in　surface　protein　patterns,　morphologies,　polarities　and　in-situ　generation　of　therapeu-tics,　of　natural　cells　have　drawn　more　attention　for　developing　advanced　drug　delivery　systems　by　fully　taking　advantage　of　these　processes.　In　this　review,　we　revolve　around　the　dynamic　cellular　transforma-tion　behaviours　which　facilitate　targeted　therapy.　Cellular　deformation　in　geometry　shape,　spitting　smal-ler　vesicles,　activation　of　antigen　present　cells,　polarization　between　distinct　phenotypes,　local　production　of　therapeutics,　and　hybridization　with　synthetic　materials　are　involved.　Other　than　focusing　on　the　traditional　delivery　of　concrete　cargoes,　more　functional　＇handles＇　that　are　derived　from　the　cells　themselves　are　introduced,　such　as　information　exchange,　cellular　communication　and　interactions　between　cell　and　extracellular　environment.　(c)　2021　Published　by　Elsevier　B.V.