Ocean　warming　and　acidification　caused　by　global　climate　change　interferes　with　the　shell　growth　of　mollusks.　In　abalone　Haliotis　discus　hannai,　the　microstructural　changes　in　the　shell　under　stress　are　unclear,　and　the　effect　of　thermal　stress　on　biomineralization　is　unknown.　The　lack　of　gene　information　has　also　hampered　the　study　of　abalone　biomineralization　mechanisms.　In　this　study,　the　microstructure　of　reconstructed　shell　in　H.　discus　hannai　was　observed　to　determine　the　effects　of　thermal　and　acidification　stress　on　shell　growth.　Three　nacre　protein　genes,　Hdh-AP7,　Hdh-AP24,　and　Hdh-perlustrin,　were　characterized,　and　their　expression　pattern　during　shell　repair　was　measured　under　thermal　and　acidification　stress　and　compared　with　those　of　two　known　biomineralization-related　genes,　Hdh-AP-1　and　Hdh-defensin.　The　stress　resulted　in　aragonite　plates　with　corroded　or　irregular　microstructures.　The　gene　expression　of　two　nacre　proteins　(Hdh-AP7　and　Hdh-AP24),　which　directly　induce　crystal　formation,　were　more　sensitive　to　thermal　stress　than　to　acidification,　but　the　expression　of　the　regulatory　nacre　protein　(Hdh-perlustrin)　and　the　two　known　genes　(Hdh-AP-1　and　Hdh-defensin),　which　are　also　related　to　immunity,　showed　an　interlinked,　complex　pattern　change.　We　concluded　that　high　temperature　and　acidification　damages　the　shell　microstructure　by　disturbing　the　expression　pattern　of　biomineralization-related　genes.