Background:　Paraspeckle　component　1　(PSPC1)　is　overexpressed　in　various　cancer　and　correlated　with　poor　survival　in　the　patients.　However,　little　is　known　about　its　expression　and　role　in　the　progression　of　nasopharyngeal　carcinomas　(NPC).　The　purpose　of　this　study　is　to　examine　PSPC1　expression　in　NPC　and　explore　its　role　in　clinical　prognosis　of　radiation　therapy.　Methods:　The　association　of　PSPC1　expression　with　clinicopathological　features　of　109　NPC　patients　was　examined　using　partial　correlation　analysis.　Cancer　tissues　were　obtained　prior　to　clinical　treatment.　All　cases　were　diagnosed　and　pathologically　confirmed　to　be　poorly　differentiated　or　undifferentiated　NPC　without　distant　metastasis.　The　patients　were　then　treated　with　radiation　and　followed-up.　Survival　analysis　was　performed.　Results:　Partial　correlation　analysis　revealed　that　the　PSPC1　expression　in　NPC　was　correlated　with　N　classification,　recurrence,　prognosis　and　radiosensitivity　in　NPC　patients,　but　not　with　the　gender,　age,　pathohistological　pattern,　clinical　stage,　and　T　classification.　The　overexpression　of　PSPC1　was　detected　in　64　samples　(58.72%).　Kaplan-Meier　survival　analysis　revealed　that　the　overall　survival　(OS)　was　longer　in　NPC　patients　with　PSPC1　low　expression　than　that　in　those　with　PSPC1　high　expression.　Moreover,　patients　with　the　overexpression　of　PSPC1　had　a　low　progression-free　survival　and　distant　metastasis-free　survival　rate,　compared　to　those　who　had　a　low　expression　of　PSPC1.　Although　not　statistically　significant,　patients　with　high　expression　of　PSPC1　had　a　lower　locoregional　recurrence-free　survival　rate　than　those　with　low　expression,　and　the　curves　between　the　two　groups　was　well　separated.　Conclusion:　PSPC1　overexpression　was　associated　with　poor　prognosis　for　NPC,　which　might　be　a　novel　useful　biomarker　to　predict　the　response　of　NPC　to　radiation　therapy　and　its　clinical　outcome.