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author:

Yang, De-Chao (Yang, De-Chao.) [1] | Wang, Shuai (Wang, Shuai.) [2] | Weng, Xiao-Lu (Weng, Xiao-Lu.) [3] | Zhang, Hong-Xia (Zhang, Hong-Xia.) [4] | Liu, Jian-Yong (Liu, Jian-Yong.) [5] (Scholars:刘见永) | Lin, Zhonghui (Lin, Zhonghui.) [6] (Scholars:林忠辉)

Indexed by:

EI SCIE

Abstract:

Coencapsulation of chemotherapeutic agents and photosensitizers into nanocarriers can help to achieve a combination of chemotherapy and photodynamic therapy for superior antitumor effects. However, precise on-demand drug release remains a major challenge. In addition, the loaded photosensitizers usually tend to aggregate, which can significantly weaken their fluorescent signals and photodynamic activities. To address these issues, herein, a smart nanocarrier termed as singlet oxygenresponsive nanoparticle (SOR-NP) was constructed by introducing singlet oxygen (O-1(2))-sensitive aminoacrylate linkers into amphiphilic mPEG-b-PCL copolymers. Boron dipyrromethene (BDP) and paclitaxel (PTX) as model therapeutic agents were coloaded into an O-1(2)-responsive nanocarrier for realizing light-controlled drug release and combination cancer treatment. This polymeric nanocarrier could substantially relieve the aggregation of encapsulated BDP due to the presence of a long hydrophobic chain. Therefore, the formed SOR-NPBDP/PTX nanodrug could generate bright fluorescent signals and high levels of O-1(2), which could mediate cell death via PDT and rupture aminoacrylate linker simultaneously, leading to collapse of SOR-NPBDP/PTX and subsequent PTX release. The light-triggered drug release and combined anticancer effects of SOR-NPBDP/PTX were validated in HepG2 and MCF-7 cancer cells and H22 tumor-bearing mice. This study provides a promising strategy for tumor-specific drug release and selective photodynamic-chemo combination treatment.

Keyword:

combination therapy drug release fluorescence imaging O-1(2)-responsive photodynamic therapy photosensitizer

Community:

  • [ 1 ] [Yang, De-Chao]Fuzhou Univ, Coll Chem, Natl & Local Joint Biomed Engn Res Ctr Photodynam, Fuzhou 350108, Peoples R China
  • [ 2 ] [Wang, Shuai]Fuzhou Univ, Coll Chem, Natl & Local Joint Biomed Engn Res Ctr Photodynam, Fuzhou 350108, Peoples R China
  • [ 3 ] [Weng, Xiao-Lu]Fuzhou Univ, Coll Chem, Natl & Local Joint Biomed Engn Res Ctr Photodynam, Fuzhou 350108, Peoples R China
  • [ 4 ] [Zhang, Hong-Xia]Fuzhou Univ, Coll Chem, Natl & Local Joint Biomed Engn Res Ctr Photodynam, Fuzhou 350108, Peoples R China
  • [ 5 ] [Liu, Jian-Yong]Fuzhou Univ, Coll Chem, Natl & Local Joint Biomed Engn Res Ctr Photodynam, Fuzhou 350108, Peoples R China
  • [ 6 ] [Lin, Zhonghui]Fuzhou Univ, Coll Chem, Natl & Local Joint Biomed Engn Res Ctr Photodynam, Fuzhou 350108, Peoples R China
  • [ 7 ] [Liu, Jian-Yong]Fuzhou Univ, Fujian Prov Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Peoples R China
  • [ 8 ] [Liu, Jian-Yong]Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350108, Peoples R China

Reprint 's Address:

  • 刘见永 林忠辉

    [Liu, Jian-Yong]Fuzhou Univ, Coll Chem, Natl & Local Joint Biomed Engn Res Ctr Photodynam, Fuzhou 350108, Peoples R China;;[Lin, Zhonghui]Fuzhou Univ, Coll Chem, Natl & Local Joint Biomed Engn Res Ctr Photodynam, Fuzhou 350108, Peoples R China;;[Liu, Jian-Yong]Fuzhou Univ, Fujian Prov Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Peoples R China;;[Liu, Jian-Yong]Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350108, Peoples R China

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Source :

ACS APPLIED MATERIALS & INTERFACES

ISSN: 1944-8244

Year: 2021

Issue: 29

Volume: 13

Page: 33905-33914

1 0 . 3 8 3

JCR@2021

8 . 5 0 0

JCR@2023

ESI Discipline: MATERIALS SCIENCE;

ESI HC Threshold:142

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count: 17

SCOPUS Cited Count: 17

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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