Coencapsulation　of　chemotherapeutic　agents　and　photosensitizers　into　nanocarriers　can　help　to　achieve　a　combination　of　chemotherapy　and　photodynamic　therapy　for　superior　antitumor　effects.　However,　precise　on-demand　drug　release　remains　a　major　challenge.　In　addition,　the　loaded　photosensitizers　usually　tend　to　aggregate,　which　can　significantly　weaken　their　fluorescent　signals　and　photodynamic　activities.　To　address　these　issues,　herein,　a　smart　nanocarrier　termed　as　singlet　oxygen-responsive　nanoparticle　(SOR-NP)　was　constructed　by　introducing　singlet　oxygen　(1O2)-sensitive　aminoacrylate　linkers　into　amphiphilic　mPEG-b-PCL　copolymers.　Boron　dipyrromethene　(BDP)　and　paclitaxel　(PTX)　as　model　therapeutic　agents　were　coloaded　into　an　1O2-responsive　nanocarrier　for　realizing　light-controlled　drug　release　and　combination　cancer　treatment.　This　polymeric　nanocarrier　could　substantially　relieve　the　aggregation　of　encapsulated　BDP　due　to　the　presence　of　a　long　hydrophobic　chain.　Therefore,　the　formed　SOR-NPBDP/PTX　nanodrug　could　generate　bright　fluorescent　signals　and　high　levels　of　1O2,　which　could　mediate　cell　death　via　PDT　and　rupture　aminoacrylate　linker　simultaneously,　leading　to　collapse　of　SOR-NPBDP/PTX　and　subsequent　PTX　release.　The　light-triggered　drug　release　and　combined　anticancer　effects　of　SOR-NPBDP/PTX　were　validated　in　HepG2　and　MCF-7　cancer　cells　and　H22　tumor-bearing　mice.　This　study　provides　a　promising　strategy　for　tumor-specific　drug　release　and　selective　photodynamic-chemo　combination　treatment.　©　2021　American　Chemical　Society.