Reactive　distillation　is　an　important　intensification　technology　to　overcome　the　unfavorable　equilibrium　conversion　for　the　direct　hydration　of　cyclohexene.　In　this　work,　a　multiphase　flow　and　multicomponent　reactive　transport　model　in　the　catalyst　layer　was　established.　By　virtue　of　the　model,　the　influences　of　structural　parameters　of　the　catalyst　layer,　physical　parameters　of　two-phase　fluid　and　reaction　conditions　on　the　catalyst　layer　efficiency　factor　were　investigated.　It　was　found　that　physical　parameters　of　two-phase　fluid　can　influence　the　two-phase　distribution,　thus　affecting　the　catalyst　layer　efficiency　factor.　The　catalyst　layer　efficiency　factor　decreases　slightly　with　the　rise　of　solubilities　of　cyclohexene　and　cyclohexanol,　although　concentration　of　cyclohexanol　and　reaction　conversion　can　be　improved　by　the　addition　of　co-solvents.　Furthermore,　it　was　found　that　the　catalyst　layer　efficiency　factor　is　independent　on　structural　parameters　approximately.　Therefore,　the　design　of　process-specific　catalytic　packings　has　remarkable　difference　between　miscible　and　immiscible　reaction　systems.