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author:

杨凯 (杨凯.) [1] | 郭黛苹 (郭黛苹.) [2] | 李忠琴 (李忠琴.) [3] | 许小平 (许小平.) [4]

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Abstract:

研究了生物不对称还原肾上腺酮生成单一对映体R-肾上腺素.以肾上腺酮为前体,从土壤中筛选到一株对肾上腺酮具有较高立体选择性催化的菌株S289,以其为出发菌株,依次进行紫外和亚硝酸诱变,得到R-肾上腺素高转化菌株UN-78.确定了最佳转化条件,在初始底物浓度为10mmol/L、摇床转速180r/min、温度30℃和pH6.5,R-肾上腺素得率达56.2%,对映体过量值8达到99.8%.

Keyword:

R-肾上腺素 手性药物 生物转化 菌种选育

Community:

  • [ 1 ] 福州大学化学化工学院,福建福州350002

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Source :

福州大学学报:自然科学版

ISSN: 1000-2243

CN: 35-1337/N

Year: 2007

Issue: 6

Volume: 35

Page: 926-930

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count: -1

30 Days PV: 3

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