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author:

潘剑茹 (潘剑茹.) [1] (Scholars:潘剑茹) | 何火聪 (何火聪.) [2] | 刘枋 (刘枋.) [3] | 饶平凡 (饶平凡.) [4]

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CQVIP CSCD

Abstract:

本研究通过嗜硫色谱、Sephadex G-75、蓝胶和POROS HQ 20离子交换色谱,从蕲蛇蛇毒中分离得到一种新组分AA-MP-I.该酶为分子量22.9 kDa的单体蛋白,等电点为5.55,不含中性糖基,N端序列为STEFQRYMEIVIVVDHSMVK,结果表明其为新型P-I型金属蛋白酶,对温度敏感,具有抗凝血活性,40℃下抗凝血活性最强,具有出血毒性,无磷脂酶A:活性.

Keyword:

出血毒 抗凝血 蕲蛇 蛇毒 金属蛋白酶

Community:

  • [ 1 ] [潘剑茹]福州大学
  • [ 2 ] [何火聪]福建省肿瘤医院
  • [ 3 ] [刘枋]福建省肿瘤医院
  • [ 4 ] [饶平凡]福州大学

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Source :

天然产物研究与开发

ISSN: 1001-6880

CN: 51-1335/Q

Year: 2010

Issue: 6

Volume: 22

Page: 929-933

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count: -1

Chinese Cited Count:

30 Days PV: 2

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