Study on asymmetric synthesis of chiral precursor R(-)-mandelic acid - Details

author：

Guo, D.-P. (Guo, D.-P..) ^[1] | Xu, X.-P. (Xu, X.-P..) ^[2] (Scholars：许小平) | Yang, K. (Yang, K..) ^[3] | Li, Z.-Q. (Li, Z.-Q..) ^[4] | Pei, B.-J. (Pei, B.-J..) ^[5]

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Scopus PKU CSCD

Abstract：

OBJECTIVE:　To　study　the　synthesis　of　chiral　precursor　R(-)-mandelic　acid　obtained　by　asymmetric　bioreduction　of　phenylglyoxylic　acid.　METHODS:　Saccharomyces　cerevisiae　strains　S.　c.　1,　S.　c.　3　and　S.　c.　10　were　selected　as　original　strains　for　further　higher　production　of　chiral　precursor　R(-)-mandelic　acid.　The　mutant　strain　S.　c.　10.　2.　8　possessing　effective　transforming　ability　and　almost　absolute　enantioselectivity　was　obtained　using　ultraviolet　and　microwave　mutagenesis.　RESULTS:　Under　the　conditions　of　initial　substrate　concentration　20　mmol·L-1,　pH　6.6,　temperature　34°C,　the　yield　and　the　enantiomeric　excesses　of　R(-)-mandelic　acid　were　85%　and　99%　respectively.　CONCLUSION:　Biotransformaton　is　a　potential　alternative　method　to　produce　chiral　precursor　R(-)-mandelic　acid.

Keyword：

Biotransformation; Chrial; R(-)-mandelic acid

Community：

[ 1 ] [Guo, D.-P.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China
[ 2 ] [Xu, X.-P.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China
[ 3 ] [Yang, K.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China
[ 4 ] [Li, Z.-Q.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China
[ 5 ] [Pei, B.-J.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China

Reprint 's Address：

郭黛苹
[Guo, D.-P.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China

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Source ：

Chinese Pharmaceutical Journal

ISSN： 1001-2494

CN： 11-2162/R

Year： 2007

Issue： 7

Volume： 42

Page： 550-553

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ESI Highly Cited Papers on the List： 0 Unfold All

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