For　the　existence　of　initial　curvature　in　curved　beams,　the　eccentrical　action　of　moving　vehicle　would　enhance　the　mechanical　difference　in　the　inner　and　outer　webs　where　the　difference　of　impact　factor　is　still　unconsidered.　Considering　the　effect　of　random　road　roughness　and　its　velocity　term,　the　bridge　model　and　12　DOFs　spatial　vehicle　model　are　discretized　by　finite　element　method,　and　the　coupled　vibration　effects　of　the　curved　bridge　under　eccentrical　vehicle　action　are　solved　using　separate　iteration　algorithm　based　on　ANSYS　program.　The　results　show　that　the　impact　factor　and　response　of　displacement　and　internal　forces　at　different　points　in　the　same　cross　section　vary　apparently,　and　the　influence　of　eccentrical　action　on　internal　forces　and　displacement　responses　in　different　position　of　the　beam　differ　largely.　The　analysis　results　would　have　great　reference　significance　for　curved　bridge　design.