Determination of three adrenergic drugs using capillary electrophoresis with amperometric detection - Details

author：

Huang, Y. (Huang, Y..) ^[1] | Zhang, X. (Zhang, X..) ^[2] | Zhan, C. (Zhan, C..) ^[3] | Chen, G. (Chen, G..) ^[4] (Scholars：陈国南)

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Scopus PKU CSCD

Abstract：

A　method　for　the　determination　of　three　adrenergic　drugs　including　phenylephrine　hydrochloride　(PHE　metaraminol　bitartrate　(MR　and　isoprenaline　hydrochloride　(IP)　was　developed　using　capillary　electrophoresis　with　amperometric　detection.　The　detection　potential　of　working　electrode　was　0.　950　V　versus　the　reference　electrode　of　Ag/AgCl.　At　the　applied　voltage　of　18　kV　the　three　analytes　were　completely　separated　within　18　min　in　50　mmol/L　bo-rate　buffer　(pH　10.　00　with　the　injection　time　of　10　s.　Good　linear　relationships　were　obtained　for　all　the　three　analytes　in　the　range　of　2　-　100　μmol/L.　The　detection　limits　for　PHE　MR　and　IP　were　0.　8　0.　8　and　1.　0　μmol/L　respectively.　The　proposed　method　was　applied　to　the　analysis　of　some　injection　drugs　and　the　results　were　satisfactory.

Keyword：

Adrenergic drugs; amperometric detection; Capillary electrophoresis (CE)

Community：

[ 1 ] [Huang, Y.]College of Chemistry and Materials Sciences, Fujian Normal University, Fuzhou 350108, China
[ 2 ] [Zhang, X.]College of Chemistry and Materials Sciences, Fujian Normal University, Fuzhou 350108, China
[ 3 ] [Zhan, C.]College of Chemistry and Materials Sciences, Fujian Normal University, Fuzhou 350108, China
[ 4 ] [Chen, G.]Ministry of Education Key Laboratory of Analysis and Detection Technology for Food Safety, Fuzhou University, Fuzhou 350108, China

Reprint 's Address：

[Huang, Y.]College of Chemistry and Materials Sciences, Fujian Normal University, Fuzhou 350108, China

Email：

huangying@fjnu.edu.en

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Source ：

Chinese Journal of Chromatography (Se Pu)

ISSN： 1000-8713

CN： 21-1185/O6

Year： 2010

Issue： 11

Volume： 28

Page： 1084-1088

1 . 2 0 0

JCR@2023

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 2

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 1

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