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The photophysical and photochemical properties of a newly developed photosensitizer α-(8-quinolinoxy) zinc phthalocyanine (α-(8-QLO) PcZn) were investigated for application in photodynamic therapy (PDT). The maximal Q band for α-(8-QLO)PcZn in dimethylformamide around 675 nm with the molar extinction coefficient of about 1.89×105 mol-1cm -1. The fluorescence quantum and singlet oxygen (1O2) yields were determined to be 0.18±0.02 and 0.62±0.03, respectively. α-(8-QLO) PcZn has a diffuse cytoplasmic distribution in nasopharyngeal carcinoma C666-1 cells, and the efficient photodynamic cytotoxicity was observed. Our findings of this study suggest that α-(8-QLO)PcZn is a promising second-generation photosensitizer for PDT. © 2009 SPIE.
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Progress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN： 1605-7422
Year： 2009
Volume： 7164
Language： English
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ESI Highly Cited Papers on the List： 0 Unfold All
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30 Days PV： 0
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