The　purpose　of　this　paper　is　to　investigate　the　influence　of　pile-soil-structure　interaction　(PSSI)　on　vibration　control　of　adjacent　buildings　with　pile　foundation.　Firstly,　assuming　that　the　adjacent　buildings　are　linked　with　the　control　actuator　of　ideal　hydraulic　servo-system,　based　on　the　Penzien　model,　the　calculation　model　of　adjacent　structures　with　pile-foundation　in　consideration　of　PSSI　is　established.　Then,　the　motion　and　control　equations　of　adjacent　structures　are　derived,　and　the　influences　of　PSSI　on　vibration　control　of　adjacent　buildings　are　analyzed.　Finally,　the　influences　of　parameters　of　soil　and　structures　on　structural　vibration　control　are　researched.　The　results　show　that　the　PSSI　has　an　obvious　influence　on　responses　of　adjacent　strutures,　and　the　change　of　control　force　of　PSSI　is　not　very　obvious;　The　parameters　of　soil　and　structures,　such　as　shear-wave　velocity　and　stiffness　of　pile,　play　a　significant　role　on　control.　©　2010　IEEE.