Land　Use　and　Coverage　Change　(LUCC)　is　an　important　aspect　of　global　change.　It　is　also　very　meaningful　to　regional　development　and　land　use　management　towards　sustainable　development.　In　this　research,　Nanjing,　as　one　representative　city　in　Yangtze　River　Delta,　one　of　the　regions　which　have　the　densest　population　and　the　quickest　economic　growth,　was　chosen　to　be　the　research　area.　Remote　Sensing　technology　is　very　popular　for　monitoring　land　use　change　and　detecting　land　use　change　areas.　In　this　research,　three　Landsat　TM/ETM　images　in　1988,　1994　and　2000　are　chosed　as　the　data,　and　classified　by　supervised　classification　method　based　on　maximum　likelihood　method　so　as　to　monitor　the　land　use　change　in　Nanjing.　And　the　spatial-temporal　analysis　models　including　land　use　structure,　transition　matrix,　gravity　centers,　have　been　used　to　analyze　the　dynamic　change　of　land　use　and　land　cover.　The　result　shows　that　the　land　use　and　land　cover　had　changed　a　lot　during　1988-2000,　especially　for　the　building　land　and　plough　land.　All　these　achievement　are　very　meaningful　and　helpful　to　the　land　policy　making　towards　sustainability.　©　2011　IEEE.