An　active　vibration　control　system　for　a　flexible　pile　isolation　was　proposed,　its　dynamic　analysis　model　was　established,　and　its　vibration　and　control　equations　were　derived.　A　typical　flexible　pile　base-isolated　structure,　as　an　example,　its　isolation　performance,　control　effect　and　the　control　effect　of　the　main　parameters　were　studied.　The　results　showed　that　the　flexible　pile　isolation　system　can　effectively　reduce　the　earthquake　response;　the　flexible　pile　of　base-isolation　system　with　active　vibration　control　can　effectively　reduce　the　collision　possibility　between　the　pile　top　and　the　casing　wall,　at　the　same　time,　the　vertical　load　of　the　structure,　the　upper　structure　stiffness　and　the　pile　length　have　significant　influence　on　the　control　effect　of　the　structure.