A　novel　highly　hydrophilic　polymethacrylate-based　monolithic　stationary　phase　based　on　the　copolymerization　of　2-acrylamido-2-methyl-1-propanesulfonic　acid　(AMPS)　and　pentaerythritol　triacrylate　(PETA)　was　designed　for　pressurized　capillary　electrochromatography.　A　typical　hydrophilic　interaction　chromatography　mechanism　could　be　observed　when　the　content　of　acetonitrile　(ACN)　in　the　mobile　phase　exceeded　25%.　Slight　swelling　or　shrinking　with　mobile　phases　of　different　polarity　was　observed　in　permeability　studies.　Good　retentions　and　efficient　separations　of　polar　analytes,　such　as　neutral　amides　and　phenols,　were　well　achieved　in　hydrophilic　interaction　chromatography　mode　with　only　about　50%　ACN　content　in　the　mobile　phase.　It　was　remarkably　lower　than　the　content　of　ACN　(＞90%)　used　on　the　hydrophilic　polymethacrylate-based　monoliths　reported　previously.　Additionally,　a　mixed　mode　of　hydrophilic　interaction　(HI)　and　strong　cation-exchange　(SCX)　could　be　also　obtained　in　the　analysis　of　charged　peptides,　and　high　column　efficiency　up　to　80,000.　plates/m　was　achieved　without　peak　tailing.　The　prepared　hydrophilic　stationary　phase　might　provide　a　potential　environmental　friendly　separation　media　for　polar　solutes　as　it　consumes　a　low　volume　of　organic　solvents.　©　2011　Elsevier　B.V.