A　series　of　novel　zinc(II)　phthalocyanines　tetra-substituted　or　mono-substituted　with　piperazinyl　moieties　linked　by　different　ethoxy　chains　has　been　prepared　and　characterized.　The　effects　of　the　N-protecting　group　of　piperazinyl　moiety,　length　of　ethoxy　chains　and　number　of　substitutes　on　the　photophysical,　photochemical　properties,　cellular　uptakes　and　in　vitro　photodynamic　antifungal　activities　have　also　been　examined.　All　of　these　compounds　are　essentially　non-aggregated　and　good　singlet　oxygen　generators　with　quantum　yields　(ΦΔ)　of　0.54-0.77　in　N,N-dimethylformamide.　The　photodynamic　activity　of　these　compounds　against　Candida　albicans　follows　the　order:　7　＞　5a　＞　5b　＞　4a　≈　4b.　The　mono-substituted　phthalocyanine　7　exhibits　the　highest　photodynamic　inactivation　of　C.　albicans　with　an　IC90　value　of　9　μM,　which　can　be　attributed　to　its　better　amphiphilicity　and　even　higher　cellular　uptake.　The　results　suggest　that　phthalocyanine　7　is　a　potential　photosensitizer　for　antifungal　photodynamic　therapy.　©　2013　Elsevier　B.V.　All　rights　reserved.