Objective:　Although　the　toxicological　effects　of　acrylamide　are　affirmative　with　animals,　the　extrapolation　of　the　conclusion　to　human　can　be　supported　by　neither　epidemiological　results　nor　the　common　knowledge　about　foods　in　question.　There　is　a　strong　possibility　that　the　presence　of　MRPs　with　acrylamide　may　alter　acrylamide＇　s　toxicological　effects.　Methods:　To　test　this　hypothesis,　a　preliminary　animal　test　was　carried　out　to　investigate　the　effect　of　arginine-glucose　MRPs　on　the　acrylamide　toxicity　and　a　high　performance　liquid　chromatography　method　was　carried　out　to　determine　the　concentration　of　acrylamide.　The　feed　intake　and　vital　signs　were　observed　and　recorded,　through　the　test,　and　the　body　weight,　organ　coefficients　were　determined　when　mice　were　sacrificed　at　the　end　of　the　test.　Results:　Remarkable　differences　in　vital　signs　were　observed　between　acrylamide　group　and　the　other　groups.　While　the　former　suffered　from　dull　fur,　reduced　feed　intake,　and　fatigue,　urinary　incontinence,　the　other　groups　were　similarly　normal.　A　very　significant　weight　loss　of　-0.66　±　1.57　g/mouse　was　recorded　with　acrylamide　group,　while(2.30　±　1.16)　to　(3.69　±　2.99)g/mouse　weight　gain　was　recorded　with　the　other　groups.　The　liver　coefficient　decreased　to　4.53　±　0.14　with　acrylamide　group　from　5.13　±　0.43　to　5.35　±　0.24　with　the　other　3　groups　with　no　significant　differences　in　coefficients　of　other　organs.　A　recovery　rate　of　acrylamide　was　72.8%　after　interacting　with　MRPs.　Conclusions:　The　presence　of　the　MRPs　with　acrylamide　has　apparently　brought　all　the　parameters　back　to　the　same　with　the　control,　and　MRPs　alone　group,　implying　that　the　MRPs　could　neutralized　the　toxicological　effects　of　acrylamide.　The　present　results　indicate　a　promising　approach　to　solving　the　puzzle　of　acrylamide　in　foods.　©　2015,　Editorial　Office　of　Journal　of　CIFST.　All　right　reserved.