The　substructure　of　the　mid-story　isolated　structure　was　similar　to　seismic　resistant　system.　It　probably　generated　elastic-plastic　deformation　under　strong　near-field　pulse-like　ground　motion.　Excessive　deformation　of　the　isolation　layer　may　also　occur,　which　will　destroy　the　isolation　bearings　and　result　in　the　overturning　collapse　of　the　superstructure.　The　artificial　generated　near-field　pulse-like　ground　motion　was　simulated　by　combining　the　real　near-field　non-pulse　ground　motion　with　simple　equivalent　pulse,　and　the　different　dynamic　behaviors　of　the　mid-story　isolated　structure　using　LRBs　(Lead-Rubber　Bearings)　were　studied　under　near-field　pulse-like　and　common　(far-field　or　non-pulse)　ground　motion.　In　addition,　the　impacts　of　the　characteristic　parameters　of　near-field　ground　motion,　including　pulse　type,　pulse　contribution　factor　and　pulse　period,　on　nonlinear　responses　of　the　mid-isolated　structure　and　maximum　deformation　of　the　isolation　layer　were　discussed.　Also,　the　mid-story　hybrid　isolation　with　viscous　dampers　installed　on　the　isolation　story　was　developed　to　limit　deformation　of　the　isolation　layer,　and　the　optimization　law　of　viscous　dampers　was　explored.　The　results　show　that　the　nonlinear　responses　of　the　mid-story　isolated　structure　and　the　maximum　deformation　of　the　isolation　layer　subjected　to　near-field　pulse-like　ground　motion　are　much　greater　than　those　under　common　ground　motion,　and　they　are　affected　by　some　parameters,　such　as　pulse　type,　pulse　contribution　factor,　pulse　period　and　PGV/PGA.　The　maximum　deformation　of　the　isolation　layer　significantly　exceeds　the　allowable　deformation　of　Lead-Rubber　Bearings,　which　destroys　the　Lead-Rubber　Bearings　and　further　results　in　the　superstructure＇s　collapse.　It　is　also　found　that　the　mid-story　hybrid　isolation　using　the　optimal　viscous　dampers　can　significantly　reduce　the　nonlinear　responses,　and　can　reduce　the　maximum　deformation　of　the　isolation　layer,　avoiding　the　superstructure＇s　overturning　collapse.　©　2015,　Editorial　Board　of　Journal　of　Basic　Science　and　Engineering.　All　right　reserved.