In　this　paper,　we　study　the　control　of　the　traffic-driven　epidemic　spreading　by　immunization　strategy.　We　consider　the　random,　degree-based　and　betweenness-based　immunization　strategies,　respectively.　It　is　found　that　the　betweenness-based　immunization　strategy　can　most　effectively　prevent　the　outbreak　of　traffic-driven　epidemic.　Besides,　we　find　that　the　critical　number　of　immune　nodes　above　which　epidemic　dies　out　is　increased　with　the　enhancement　of　the　spreading　rate　and　the　packet-generation　rate.　©　2015　Elsevier　B.V.　All　rights　reserved.