Although　poly(l-lactic　acid)　(PLLA)　is　reputed　to　be　biodegradable　in　the　human　body,　its　hydrophobic　nature　lets　it　persist　for　ca.　5.5　years.　This　study　demonstrates　that　biologically　safe　lactide　copolymers,　poly(aspartic　acid-co-l-lactide)　(PAL)　and　poly(malic　acid-co-l-lactide)　(PML),　dispersed　in　the　PLLA　function　as　detonators　(triggers)　for　its　hydrolytic　degradation　under　physiological　conditions.　The　copolymers　significantly　enhance　hydrolysis,　and　consequently,　the　degradation　rate　of　PLLA　becomes　easily　tunable　by　controlling　the　amounts　of　PAL　and　PML.　The　present　study　elucidates　the　effects　of　uniaxial　drawing　on　the　structural　development,　mechanical　properties,　and　hydrolytic　degradation　under　physiological　conditions　of　PLLA　blend　films.　At　initial　degradation　stages,　the　mass　loss　was　not　affected　by　uniaxial　drawing;　however,　at　late　degradation　stages,　less　developed　crystals　as　well　as　amorphous　chains　were　degradable　at　low　draw　ratio　(DR),　whereas　not　only　highly　developed　crystals　but　also　the　oriented　amorphous　chains　became　insensitive　to　hydrolysis　at　high　DR.　Our　work　provides　important　molecular　level　results　that　demonstrate　that　biodegradable　materials　can　have　superb　mechanical　properties　and　also　disappear　in　a　required　time　under　physiological　conditions.　©　2017　American　Chemical　Society.