Synergistic Chemopreventive and Therapeutic Effects of Co-drug UA-Met: Implication in Tumor Metastasis - Details

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Abstract：

The　anticancer　properties　of　ursolic　acid　(UA)　and　metformin　(Met)　have　been　well　demonstrated.　However,　whether　these　compounds　can　act　synergistically　to　prevent　and　treat　cancer　is　not　known.　We　present　in　this　study,　the　synergism　between　UA　and　Met,　and　that　of　a　new　codrug　made　of　UA　and　Met　(UA-Met)　against　several　cancer　cell　lines.　The　combination　of　high　concentration　of　UA　(25,　50,　75,　100　μM)　and　Met　(5,　10,　20,　40　mM)　resulted　in　synergetic　cytotoxicity　on　MDA-MB-231　and　MCF-7　cells　(CI　©　2017　American　Chemical　Society.

Keyword：

Carboxylic acids Cell culture Cells Diseases Glycoproteins Mammals Pathology Tumors

Community：

[ 1 ] [Zheng, Guirong]Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University2, Fuzhou University, Sunshine Technology Building 6FL, #605, Minhou District, Fuzhou, Fujian; 350116, China
[ 2 ] [Shen, Zhichun]Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University2, Fuzhou University, Sunshine Technology Building 6FL, #605, Minhou District, Fuzhou, Fujian; 350116, China
[ 3 ] [Xu, Aixiao]Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University2, Fuzhou University, Sunshine Technology Building 6FL, #605, Minhou District, Fuzhou, Fujian; 350116, China
[ 4 ] [Jiang, Kai]Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University2, Fuzhou University, Sunshine Technology Building 6FL, #605, Minhou District, Fuzhou, Fujian; 350116, China
[ 5 ] [Wu, Pengyu]Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University2, Fuzhou University, Sunshine Technology Building 6FL, #605, Minhou District, Fuzhou, Fujian; 350116, China
[ 6 ] [Yang, Xiang]Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University2, Fuzhou University, Sunshine Technology Building 6FL, #605, Minhou District, Fuzhou, Fujian; 350116, China
[ 7 ] [Chen, Xian]Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University2, Fuzhou University, Sunshine Technology Building 6FL, #605, Minhou District, Fuzhou, Fujian; 350116, China
[ 8 ] [Shao, Jingwei]Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University2, Fuzhou University, Sunshine Technology Building 6FL, #605, Minhou District, Fuzhou, Fujian; 350116, China

Reprint 's Address：

[shao, jingwei]cancer metastasis alert and prevention center, pharmaceutical photocatalysis of state key laboratory of photocatalysis on energy and environment, fujian provincial key laboratory of cancer metastasis chemoprevention and chemotherapy, college of chemistry, fuzhou university2, fuzhou university, sunshine technology building 6fl, #605, minhou district, fuzhou, fujian; 350116, china

Email：

shaojingwei@fzu.edu.cn

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Source ：

Journal of Agricultural and Food Chemistry

ISSN： 0021-8561

Year： 2017

Issue： 50

Volume： 65

Page： 10973-10983

3 . 4 1 2

JCR@2017

5 . 7 0 0

JCR@2023

ESI HC Threshold：157

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

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