Recently,　nanoparticles　self-assembled　from　amphiphilic　supramolecular　linear-dendritic　block　copolymers　(LDBCs)　have　attracted　great　interest,　since　the　combination　of　linear　and　dendritic　polymers　can　incorporate　the　unique　properties　of　the　different　segments　but　avoid　some　inherent　drawbacks　of　dendrimers,　not　to　mention　that　the　components　can　be　flexibly　adjusted　to　enrich　their　functionality.　In　this　study,　LDBCs　formed　by　host-guest　recognition　of　polyacetal　dendrimers　with　a　β-cyclodextrin　core　and　adamantane-terminated　zwitterionic　poly(sulfobetaine)　could　self-assemble　into　micelles　and　vesicles　by　varying　the　hydrophilic/hydrophobic　ratio.　Owing　to　the　acid-labile　characteristic　of　the　dendritic　segments,　the　micelles　and　vesicles　were　degradable　and　could　release　their　payloads　in　a　pH-responsive　manner.　The　incorporation　of　zwitterionic　linear　segments　gave　the　micelles　and　vesicles　a　charge-reversal　ability　and　excellent　resistivity　to　protein　absorption,　leading　to　higher　affinity　to　cell　membranes　than　conventional　PEG-coated　nanoparticles.　In　addition,　the　potential　of　these　nanoparticles　as　anticancer　drug　carriers　was　preliminarily　evaluated　by　using　doxorubicin　as　a　model　drug　and　the　results　indicated　that　the　DOX-loaded　micelles　and　vesicles　exhibited　remarkable　anticancer　activity.　This　study　cast　a　new　light　on　the　application　of　dendrimers　and　these　micelles　and　vesicles　constructed　from　LDBCs　may　be　promising　candidates　as　anticancer　drug　delivery　platforms　for　cancer　therapy.　©　The　Royal　Society　of　Chemistry　2017.