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author:

Lv, Shuzhen (Lv, Shuzhen.) [1] | Li, Yi (Li, Yi.) [2] | Zhang, Kangyao (Zhang, Kangyao.) [3] | Lin, Zhenzhen (Lin, Zhenzhen.) [4] | Tang, Dianping (Tang, Dianping.) [5]

Indexed by:

EI

Abstract:

A class of 0-dimensional/2-dimensional (0D/2D) nanoheterostructures based on carbon quantum dots (CQDs) and graphitic carbon nitride (g-C3N4) was designed as the signal-generation tags for the sensitive photoelectrochemical (PEC) immunoassay of prostate-specific antigen (PSA) coupling with the copper nanoclusters (CuNCs). Combination of CQDs with g-C3N4 promoted the photoexcited electron/hole separation and largely increased the photocurrents of the nanoheterostructures. Initially, a sandwich-type immunoreaction was carried out on monoclonal anti-PSA antibody-coated microplate by using PSA aptamer linked with CuNCs as the tracer. Accompanying the immunocomplex, the carried CuNCs were dissolved under acidic conditions. The as-released copper ions from the CuNCs could be captured onto the CQDs/g-C3N4 nanoheterostructures via the amino-group on the CQD surface as well as the -NHx (x = 1, 2, 3) of g-C3N4 nanosheets. The strong coordination of the Lewis basic sites on the CQDs/g-C3N4 with Cu2+ decreased the photocurrent of the nanoheterostructures. Under optimal conditions, CQDs/g-C3N4 nanoheterostructures displayed good photocurrent responses for the detection of PSA within the dynamic linear range of 0.02-100 ng mL-1 and a limit of detection (LOD) of 5.0 pg mL-1. This method was also evaluated for quantitative screening of human PSA serum specimens by using the referenced electrochemiluminescent enzyme-linked immunoassay (ECL-ELIA) and gave good matched results between two methods. Additionally, this system was beneficial to explore the charge-separation and photoinduced electron transfer mechanism in the photoelectrochemical sensing protocols. © 2017 American Chemical Society.

Keyword:

Antigens Carbon nitride Electron transitions Immunology Metal ions Nanoclusters Nanocrystals Nitrides Photocurrents Photoelectrochemical cells Semiconductor quantum dots Signal generators

Community:

  • [ 1 ] [Lv, Shuzhen]Key Laboratory of Analytical Science of Food Safety and Biology, MOE and Fujian Province, State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry, Fuzhou University, Fuzhou; 35011168, China
  • [ 2 ] [Li, Yi]Key Laboratory of Analytical Science of Food Safety and Biology, MOE and Fujian Province, State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry, Fuzhou University, Fuzhou; 35011168, China
  • [ 3 ] [Zhang, Kangyao]Key Laboratory of Analytical Science of Food Safety and Biology, MOE and Fujian Province, State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry, Fuzhou University, Fuzhou; 35011168, China
  • [ 4 ] [Lin, Zhenzhen]Key Laboratory of Analytical Science of Food Safety and Biology, MOE and Fujian Province, State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry, Fuzhou University, Fuzhou; 35011168, China
  • [ 5 ] [Tang, Dianping]Key Laboratory of Analytical Science of Food Safety and Biology, MOE and Fujian Province, State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry, Fuzhou University, Fuzhou; 35011168, China

Reprint 's Address:

  • [li, yi]key laboratory of analytical science of food safety and biology, moe and fujian province, state key laboratory of photocatalysis on energy and environment, department of chemistry, fuzhou university, fuzhou; 35011168, china

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Source :

ACS Applied Materials and Interfaces

ISSN: 1944-8244

Year: 2017

Issue: 44

Volume: 9

Page: 38336-38343

8 . 0 9 7

JCR@2017

8 . 5 0 0

JCR@2023

ESI HC Threshold:306

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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