A　facile　and　versatile　approach　for　the　preparation　of　super-hydrophilic,　excellent　antifouling　and　hemocompatibility　membranes　had　been　developed　through　the　generation　in　situ　of　bio-inspired　polydopamine　(PDA)　microspheres　on　PVDF　membranes.　SEM　images　showed　that　the　PDA　microspheres　were　uniformly　dispersed　on　the　upper　surface　and　the　lower　surface　of　the　modified　membranes.　And　there　were　a　great　number　of　PDA　microspheres　immobilized　on　the　cross-section,　but　the　interconnected　pores　structure　was　not　destroyed.　These　facts　indicated　the　existence　of　membrane　micro-reactor　effect　for　the　whole　membrane　structure.　Considering　the　remarkable　improvement　of　hydrophilicity,　antifouling　properties,　and　permeation　fluxes,　we　also　proposed　the　cluster　phenolic　hydroxyl　effect　for　the　PVDF/PDA　hybrid　membranes.　And　the　cluster　phenolic　hydroxyl　effect　can　be　ascribed　to　the　all　directions　distributed　phenolic　hydroxyl　groups　on　the　whole　membrane　structure.　Besides,　the　self-driven　filtration　experiments　showed　the　great　wetting　ability　and　permeability　of　the　PVDF/PDA　hybrid　membranes　in　filtration　process　without　any　external　pressure.　This　implied　the　existence　of　accelerating　self-driven　force　after　the　water　flow　flowed　into　the　internal　of　membranes,　which　contributed　to　the　increase　of　water　flow　velocity.　All　the　three　aspects　were　in　favor　of　the　enhancement　of　hydrophilicity,　antifouling　properties　and　permeability　of　the　modified　membranes.　Moreover,　the　conventional　filtration　tests,　oil/water　emulsion　filtration　tests　and　protein　adsorption　tests　were　also　carried　out　to　discuss　the　practical　applications　of　PVDF/PDA　hybrid　membranes.　And　the　hemocompatibility　of　the　modified　membranes　was　also　proved　to　enhance　greatly　through　the　hemolysis　tests　and　platelet　adhesion　tests,　indicating　that　the　membranes　were　greatly　promising　in　biomedical　applications.　The　strategy　of　material　modification　reported　here　is　substrate-independent　and　can　be　extended　to　other　substrate　materials,　and　allows　the　development　of　novel　functional　membranes　through　secondary　treatments.　©　2018　Elsevier　B.V.