miRNAs　such　as　miR-148b　play　crucial　regulatory　role　in　tumor　metastasis,　but　their　applications　are　limited　because　they　are　easy　to　degrade　in　serum　conditions　and　lack　targeting　ability.　Herein,　CC9-PEG-SSBPEI　was　synthesized　and　used　as　nano-carrier　for　miR-148b.　DLS　and　gel　retardation　analyses　indicated　that　CC9-PEG-SSBPEI　could　combine　with　miR-148b　by　charge　interaction　and　formed　into　nanoparticles　with　the　size　changed　from　811.6　nm　to　146.4　nm.　CC9-PEG-SSBPEI　could　protect　miR-148b　from　RNase　A　degradation　and　showed　a　reduction　sensitive　release　of　miR-148b.　FACS　analysis　and　CLSM　images　displayed　that　the　conjugated　CC9　peptide　improved　the　accumulation　and　penetration　of　the　nanoparticles　in　HuH-7　liver　cancer　cells　through　binding　with　the　target　of　miR-148b　neuropilin-1(NRP-1)　on　the　cell　surface.　The　raised　level　of　miR-148b　in　turn　inhibited　the　expression　of　NRP-1　and　suppressed　the　migration　of　HuH-7　liver　cancer　cells.　Moreover,　hemolysis　and　cytotoxicity　assay　demonstrated　that　the　nanoparticles　had　good　hemo-　and　cyto-　compatibility.　Hence,　CC9-PEG-SSBPEI/miR-148b　nanoparticles　had　the　potential　for　targeting　delivery　of　miR-148b　and　anti-metastasis　of　hepatocellular　carcinoma　(HCC)　cells.　©　2019　Elsevier　B.V.