Abstract:　The　influences　of　acidic　properties　and　pore　structures　of　H-Beta　and　H-ZSM-5　zeolites　on　the　reaction　properties　of　n-butane　isomerization　at　low　temperatures　were　investigated.　The　results　showed　that　bimolecular　pathway　of　n-butane　conversion　predominates　over　H-ZSM-5　zeolites,　while　the　monomolecular　and　bimolecular　pathways　occur　simultaneously　over　H-Beta　zeolites.　The　conversion　rate　of　n-butane　strongly　relies　on　the　amount　of　strong　Brønsted　acid　sites　regardless　of　zeolite　topology.　However,　the　topology　of　zeolites　crucially　determines　the　products　distribution,　and　the　density　of　strong　Brønsted　acid　sites　plays　a　secondary　role.　The　cavities　of　zeolites,　formed　in　the　intersections　of　channels,　provide　the　places　for　the　bimolecular　reaction.　The　formation　of　trimethyl　C8　intermediates　is　spatially　restricted　in　the　narrow　channel　intersections　of　H-ZSM-5　zeolites,　resulting　in　higher　contribution　of　n-butane　disproportionation　reaction.　In　addition,　the　narrow　pore　channels　of　H-ZSM-5　zeolite　limit　the　monomolecular　isomerization　of　n-butane　molecules　and　affect　the　diffusion　of　heavier　products　(pentane)　produced　from　bimolecular　reaction,　leading　to　the　severe　secondary　reaction　and　high　selectivity　to　propane.　In　contrast,　the　pore　channels　of　H-Beta　zeolite　allow　the　monomolecular　isomerization　of　n-butane　and　the　deposition　of　coke.　Graphical　Abstract:　The　topology　of　zeolites　crucially　determines　the　products　distribution.[Figure　not　available:　see　fulltext.].　©　2019,　Springer　Science+Business　Media,　LLC,　part　of　Springer　Nature.