Deactivation　caused　by　the　aggregation　of　Pt　nanoparticles　is　a　critical　issue　for　the　high-temperature　propane　dehydrogenation　(PDH)　reaction.　Carbon　nanotubes　(CNTs)　that　were　rich/poor　in　defects　(CNTs-RD/CNTs-PD)　were　applied　as　supports　for　the　PDH　reaction.　Pt　nanoparticles　supported　on　defect-rich　CNTs　(Pt/CNTs-RD)　showed　much　higher　performance　and　stability　during　the　PDH　reaction　than　those　supported　on　defect-poor　CNTs.　X-ray　photoelectron　spectroscopy　(XPS)　results　showed　that　there　was　little　change　between　the　fresh　and　spent　Pt/CNTs-RD　catalysts.　High-resolution　transmission　electron　microscopy　(HRTEM)　and　simulation　results　both　suggested　the　presence　of　strong　metal-support　interactions　between　the　defects　and　Pt　nanoparticles　that　could　effectively　inhibit　the　agglomeration　of　Pt　nanoparticles,　increase　the　anti-coking　ability,　and　thus　enhance　the　stability　and　activity　of　Pt/CNTs-RD　during　the　high-temperature　PDH　reaction.　The　oxygen-containing　groups　and　confinement　effect　of　CNTs　had　a　weaker　influence　on　the　catalyst　activity.　©　2018