This　study　aimed　to　evaluate　the　mechanical　and　bioactive　performances　of　lithium　disilicate　glass-ceramic　mixtures　produced　from　the　SiO2-Li2O-ZrO2-K2O-P2O5-Al2O3　system　by　sol-gel　and　melting　methods.　The　microstructure　and　constituent　of　the　samples　were　characterized　by　XRD,　FTIR,　SEM　and　EDS　analyses.　The　flexural　strength　was　analyzed　using　3-point　bending　tests,　and　the　bioactive　behavior　was　evaluated　by　immersion　test　in　simulated　body　fluid　(SBF)　solution.　Compared　with　the　samples　prepared　by　single　method,　the　results　suggested　that　the　lithium　disilicate　glass-ceramic　mixtures　combined　by　sol-gel　and　melting　methods　form　better　cross-linked　interlocking　microstructure　to　achieve　higher　flexural　strength,　simultaneously　with　excellent　bioactive　performance,　which　could　be　a　promising　candidate　for　restorative　dental　biomedical　application.　©　2019　Elsevier　B.V.