On-demand　delivery　of　drug　to　deep　tumor　tissues　with　long-term　tumor　retention　has　directly　influence　on　therapeutic　efficiency　and　prognosis　of　patients,　which　still　remains　challenge　in　cancer　therapy.　Here　we　introduce　metallo-supramolecular　nanoflowers　through　multi-drugs　and　metal　coordination　effect　for　near-infrared　(NIR)　or　acidic-triggered　multi-drugs　release,　long-term　accumulation　at　tumor　tissues　and　NIR-II　fluorescence　imaging-guided　photo-chemotherapy.　The　nanoflowers　(refer　to　ICG⊃EDOX)　are　constructed　by　(−)-epigallocatechin-3-gallate　(EGCG),　Cu2+　ions,　indocyanine　green　(ICG)　and　doxorubicin　hydrochloride　(DOX)　through　coordination　effect,　π-π　stacking　and　hydrophobic　force.　Due　to　strong　intermolecular　interaction,　the　ICG⊃EDOX　is　superior　stable　in　physiological　conditions,　while　releases　DOX/ICG　on-demand　upon　the　acidic/NIR　laser　irradiation.　Moreover,　ICG⊃EDOX　could　penetrate　deep　tumor　tissues　with　ultralong　tumor　retention　(＞8　d)　by　microvesicle　(MVs)-mediated　intercellular　interaction.　Irradiated　by　808　nm　laser,　the　higher　NIR-II　fluorescence　signal　from　ICG⊃EDOX　in　tumors　can　effectively　guide　local　phototherapy,　and　the　synergistic　therapeutic　efficiency　of　nanoflowers　with　completely　elimination　of　tumors　is　achieved　in　comparison　with　DOX　or　DOX/ICG　treated　4T1-bearing　mice.　Overall,　the　excellent　therapeutic　effect　of　nanoflowers　may　hold　great　promise　for　the　clinic　translation.　©　2020　Elsevier　B.V.