Hydrogels　are　important　for　stretchable　and　wearable　multifunctional　sensors,　but　their　application　is　limited　by　their　low　mechanical　strength　and　poor　long-term　stability.　Herein,　a　conductive　organohydrogel　with　a　3D　honeycomb　structure　was　prepared　by　integrating　carbon　nanotubes　(CNTs)　and　carbon　black　(CB)　into　a　poly(vinyl　alcohol)/glycerol　(PVA/Gly)　organohydrogel.　Such　a　nanocomposite　organohydrogel　is　built　on　a　physical　cross-linking　network　formed　by　the　hydrogen　bonds　among　PVA,　glycerol,　and　water.　CNTs　and　CB　had　an　add-in　synergistic　impact　on　the　mechanical　and　electrical　performances　of　the　PVA/Gly　organohydrogel　because　of　the　distinct　aspect　ratios　and　geometric　shapes.　The　prepared　organohydrogel　integrated　with　a　tensile　strength　of　4.8　MPa,　a　toughness　of　15.93　MJ　m-3,　and　flexibility　with　an　elongation　at　break　up　to　640%.　The　organohydrogels　also　showed　good　antifreezing　feature,　long-term　moisture　retention,　self-healing,　and　thermoplasticity.　Sensors　designed　from　these　organohydrogels　displayed　high　stretching　sensitivity　to　tensile　strain　and　temperature,　with　a　gauge　factor　of　2.1　within　a　relatively　broad　strain　range　(up　to　∼600%　strain),　a　temperature　coefficient　of　resistance　of　-0.935%·°C-1,　and　long-term　durability.　The　sensors　could　detect　full-range　human　physiological　signals　and　respond　to　the　change　in　temperature,　which　are　highly　desired　for　multifunctional　wearable　electronic　devices.　©　2020　American　Chemical　Society.