Opposite salt-dependent stability of i-motif and duplex reflected in a single DNA hairpin nanomachine - Details

author：

Zhang, Fang (Zhang, Fang.) ^[1] | Liu, Biwu (Liu, Biwu.) ^[2] | Lopez, Anand (Lopez, Anand.) ^[3] | Wang, Shaoyun (Wang, Shaoyun.) ^[4] | Liu, Juewen (Liu, Juewen.) ^[5]

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Abstract：

We　herein　report　a　DNA　hairpin　structure　containing　a　polycytosine　loop　region,　and　this　hairpin　can　operate　like　a　nanomachine　allowing　independently　controlled　stability　of　the　i-motif　loop　and　duplex　stem　region.　This　was　made　possible　by　the　opposite　salt-dependent　stability　of　DNA　duplex　and　hairpin,　thus　providing　a　new　method　for　designing　molecular　devices　or　switches　design.　A　singly-labeled　fluorescent　method　was　used　to　measure　the　stability　of　an　i-motif　DNA　in　the　presence　of　various　metal　ions.　Salt　in　general　destabilizes　the　i-motif　but　stabilizes　duplex　DNA,　allowing　us　to　engineer　an　i-motif　containing　hairpin　for　modulating　the　stability　of　each　secondary　structure　independently.　©　2020　IOP　Publishing　Ltd.

Keyword：

DNA Metal ions Metals Nanotechnology Stability

Community：

[ 1 ] [Zhang, Fang]College of Biological Science and Engineering, Fuzhou University, Fuzhou; 350108, China
[ 2 ] [Zhang, Fang]Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo; ON; N2L 3G1, Canada
[ 3 ] [Liu, Biwu]Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo; ON; N2L 3G1, Canada
[ 4 ] [Lopez, Anand]Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo; ON; N2L 3G1, Canada
[ 5 ] [Wang, Shaoyun]College of Biological Science and Engineering, Fuzhou University, Fuzhou; 350108, China
[ 6 ] [Liu, Juewen]Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo; ON; N2L 3G1, Canada

Reprint 's Address：

[zhang, fang]college of biological science and engineering, fuzhou university, fuzhou; 350108, china;;[zhang, fang]department of chemistry, waterloo institute for nanotechnology, university of waterloo, waterloo; on; n2l 3g1, canada

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Source ：

Nanotechnology

ISSN： 0957-4484

Year： 2020

Issue： 19

Volume： 31

3 . 8 7 4

JCR@2020

2 . 9 0 0

JCR@2023

ESI HC Threshold：196

JCR Journal Grade：2

CAS Journal Grade：3

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 7

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

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