Harmful　bacteria　have　seriously　threatened　human　health　and　wealth　for　a　long　time.　Herein,　a　multifunctional　drug　delivery　system　based　on　UiO-66　was　fabricated,　and　it　showed　potent　synergistic　antibacterial　effects　when　used　in　conjunction　with　photodynamic　therapy　and　chemotherapy.　First,　UiO-66-NH2　was　prepared　via　a　facile　solvothermal　method.　Then,　carboxylic　zinc　phthalocyanine,　a　broad-spectrum　photosensitizer,　was　connected　to　UiO-66-NH2　by　amidation.　Next,　synergistic　chemical　antibiotic　linezolid　was　loaded　in　the　pores,　and　lysozyme　was　coated　on　the　surface　by　electrostatic　interactions.　In　vitro　antibacterial　experiments　were　then　carried　out　to　evaluate　the　antibacterial　effects　of　this　system　against　three　kinds　of　bacteria,　Staphylococcus　aureus,　Escherichia　coli,　and　methicillin-resistant　S.　aureus　(MRSA).　The　combination　of　lysozyme,　linezolid,　and　singlet　oxygen　generated　by　irradiation　of　the　photosensitizers　resulted　in　a　potent　antibacterial　effect　against　S.　aureus,　E.　coli,　and　even　MRSA,　which　demonstrates　the　synergistic　antibacterial　efficacy　of　photodynamic　therapy　and　chemotherapy.　Copyright　©　2020　American　Chemical　Society.