Base　on　the　shaking　table　model　tests,　the　numerical　simulations　are　further　carried　out　to　quantitatively　study　the　seismic　responses　of　weak　interlayered　slope　with　anchor-frame　reinforcement.　The　amplification　coefficient　of　peak　horizontal　acceleration　increases　non-linearly　with　elevation　and　the　whiplash　effect　is　observed　evidently.　However,　the　existence　of　weak　interlayer　changes　the　performance　of　elevation　effect　in　the　vicinity　of　interlayer　and　the　isolation　effect　is　observed　under　the　scenario　of　large　amplitude　excitation.　The　positive　and　negative　oscillation　coefficients　of　peak　earth　pressure　are　basically　equaled　under　small　amplitude　excitation.　Under　the　lager　amplitude　excitation,　however,　the　minimum　response　of　earth　pressure　tends　to　zero　(almost　detached)　and　the　maximum　response　of　earth　pressure　reaches　4~7　times　of　static　one.　The　WC　wave　is　abundant　with　high-frequency　component,　whose　predominant　frequency　is　close　to　the　natural　frequency　of　slope.　Therefore,　the　responses　of　slope　acceleration　and　earth　pressure　under　the　excitation　of　WC　wave　are　greater　than　other　waves.　The　aforementioned　seismic　responses　reflected　by　numerical　simulations　agree　with　the　shaking　table　model　tests　in　generally.　In　quantitatively,　however,　the　amplification　coefficient　of　peak　horizontal　acceleration　at　the　top　of　slope　and　the　positive　oscillation　coefficients　of　peak　earth　pressure　are　significantly　greater　than　their　counterparts　from　shaking　table　model　tests.　The　shortcomings　in　shaking　table　tests,　such　as　extra-strong　design　of　similar　material　and　the　lack　of　instrumentation,　should　be　improved　in　the　further　studies.　©　2020,　The　Editorial　Board　of　Journal　of　Basic　Science　and　Engineering.　All　right　reserved.