In　this　paper,　a　hybrid　control　system　of　the　energy　dissipation　and　isolation　of　flexible　pile(EDIPF)　is　proposed,　the　dynamic　analysis　model　of　system　is　established,　and　its　vibration　and　control　equations　are　derived.　Taking　a　typical　flexible　pile　base-isolated　structure　for　example,　the　isolation　performance,　control　effect　and　main　control　parameters　are　studied.　The　results　show　that:　the　isolation　and　energy　dissipation　system　of　flexible　pile　can　effectively　reduce　the　seismic　responses　of　structure,　and　to　apply　active　control　to　this　system　can　reduce　the　possibility　of　collision　between　pile　and　wall　of　pile　hole.　At　the　same　time,　the　vertical　loads　and　the　stiffness　of　superstructure　and　piles　have　a　significant　influence　on　the　control　effect　of　structures.