Base　on　Tersoff　and　Lernnard-Jones　potentials,　molecular　dynamics　simulation　of　nanoindentation　experiment　on　single　layer　rectangular　graphene　film　is　carried　out.　A　typical　force-displacement　curve　is　obtained　and　the　effects　of　various　factors　including　indenter　radius,　velocities　as　well　as　boundary　conditions　on　the　simulation　results　are　discussed.　The　Young＇s　modulus　and　the　strength　of　the　graphene　are　measured　as　1　terepascals　and　90　gigapascals,　respectively.