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学者姓名：傅南雁
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Abstract ：
The processes of ferroptosis and drug-induced liver injury (DILI) correlate closely to oxidative stress in mitochondria which will affect intracellular microenvironmental parameters such as lysosomal viscosity. Therefore, it is of great significance to dynamically monitor ONOO- in mitochondria and viscosity in lysosomes for understanding redox signal transduction but remains challenging. Here we report a near-infrared fluorescent probe, HCy-OH-mito, which has the dual-organelle targeting ability for the detection of ONOO- in mitochondria and viscosity in lysosomes via a "three-key-and-lock" strategy. HCy-OH-mito has been successfully applied to independently and simultaneously label mitochondria and lysosomes in live cells, and monitor the fluctuations of ONOO- in mitochondria and viscosity in lysosomes during ferroptosis and APAP-induced liver injury and in live zebrafish.
Keyword ：
Fluorescent probe Dual Fluorescent probe Dual induced liver injury (DILI) induced liver injury (DILI) in mitochondria and viscosity in lysosomes Ferroptosis and drug in mitochondria and viscosity in lysosomes Ferroptosis and drug organelle targeting ONOO organelle targeting ONOO
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| GB/T 7714 | Liu, Yunfan , Wang, Xuyan , Fu, Nanyan et al. "Three-key-and-lock" near-infrared fluorescent probe for dual-channel tracking ONOO- in mitochondria and viscosity in lysosomes in ferroptosis and drug-induced liver injury [J]. | DYES AND PIGMENTS , 2024 , 225 . |
| MLA | Liu, Yunfan et al. ""Three-key-and-lock" near-infrared fluorescent probe for dual-channel tracking ONOO- in mitochondria and viscosity in lysosomes in ferroptosis and drug-induced liver injury" . | DYES AND PIGMENTS 225 (2024) . |
| APA | Liu, Yunfan , Wang, Xuyan , Fu, Nanyan , Wang, Guimei . "Three-key-and-lock" near-infrared fluorescent probe for dual-channel tracking ONOO- in mitochondria and viscosity in lysosomes in ferroptosis and drug-induced liver injury . | DYES AND PIGMENTS , 2024 , 225 . |
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A series of gold (I) phoshpine complexes with diverse alkynyl ligands [Au(C equivalent to CR)(PTA)] (R=C6H11OH, 1; C5H9OH, 2; C15H11OH, 3; C19H27O2, 4; C18H23O2, 5; C9H12N, 6; CH2OCH2C6H5, 7; C6H4OCH3, 8; PTA=1,3,5-Triaza-7-phosphaadamantane) have been synthesized and characterized using a range of spectroscopic techniques. Complex 1 and 3 show an infinite one-dimensional S-type and zigzag aurophilic chain, respectively, whereas complex 2 containing 1-ethynyl-1-cyclohexanol gives an approximate linear two-dimensional aurophilic chain, through intra/intermolecular Au(I)& ctdot;Au(I) interactions as well as hydrogen bonding interactions between hydroxy groups of alkynyl ligands and PTA. Solid complexes 1-8 display strongly room/low-temperature emissive of 477-613 nm with the emission lifetime of 0.40-14.0 mu s. All the complexes display higher cytotoxicities against MCF-7, with the cytotoxicity decreasing in the following order 4>8>5>3>7>6>2>1. Complex 4 and 5 stand out for the highest selectivity towards MCF-7 (IC50=0.63-0.78 mu M) compared with normal human embryonic lung fibroblasts (helf) (IC50=14.85-18.13 mu M), which makes those complexes attractive for breast cancer therapy.
Keyword ：
alkynyl gold (I) phoshpine complexes alkynyl gold (I) phoshpine complexes cytotoxicity cytotoxicity luminescence luminescence structure-activity relationships structure-activity relationships
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| GB/T 7714 | Lin, Tingting , Lin, Yanyan , Yao, Junfei et al. Alkynyl Gold(I) Phosphine Complexes: Evaluation of Structure-Activity Relationships for the Alkynyl Ligands on Luminescence and Cytotoxicity [J]. | EUROPEAN JOURNAL OF INORGANIC CHEMISTRY , 2024 , 27 (18) . |
| MLA | Lin, Tingting et al. "Alkynyl Gold(I) Phosphine Complexes: Evaluation of Structure-Activity Relationships for the Alkynyl Ligands on Luminescence and Cytotoxicity" . | EUROPEAN JOURNAL OF INORGANIC CHEMISTRY 27 . 18 (2024) . |
| APA | Lin, Tingting , Lin, Yanyan , Yao, Junfei , Wu, Zhongwei , Fu, Nanyan , Wei, Qiaohua . Alkynyl Gold(I) Phosphine Complexes: Evaluation of Structure-Activity Relationships for the Alkynyl Ligands on Luminescence and Cytotoxicity . | EUROPEAN JOURNAL OF INORGANIC CHEMISTRY , 2024 , 27 (18) . |
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Background: Ferroptosis, as a novel form of cell death, is becoming one of the hot topics in cancer treatment research. It differs from necrosis and autophagy in that it involves the accumulation of lipid peroxides and is triggered by iron dependency. Recent studies have suggested that this mechanism may alter the viscosity or structure of lipid droplets (LDs). The relationship between LDs viscosity and ferroptosis remains an active area of research with limited reports at present. Additionally, there is a lack of effective anticancer drugs targeting the ferroptosis pathway to promote ferroptosis in tumour cells. Therefore, the development of tools to detect viscosity changes during ferroptosis and targeted therapeutic strategies is of great significance. Results: By coupling 1,3-indandione with naphthalimide, including decamethylamine as a LDs recognition group, we designed and synthesized an environmental fluorescent probe that induces intramolecular charge transfer (TICT) effects. Notably, the diffusion and transport of intracellular substances may be affected in highly viscous environments. Under such conditions, intracellular iron ions may accumulate, leading to peroxide production and cellular damage, which can trigger ferroptosis. Therefore, WD -1 achieved excellent in situ bioimaging of LDs targeting and its viscosity during ferroptosis in HeLa cells and zebrafish. Furthermore, it was observed that WD -1 effectively differentiated between malignant and normal cells during this process, highlighting its potential significance in distinguishing cellular states. In addition, we used the antitumour drug paclitaxel to study ferroptosis in cancer cells. These findings not only provide an excellent tool for the development of the ferroptosis response, but also are crucial for understanding the biological properties of LDs during the ferroptosis response. Significance and novelty: Based on a powerful tool of fluorescent probe with in vivo bioimaging, we developed WD1 to track the impact of paclitaxel on the process of ferroptosis in living cells. Therefore, we preliminarily believe that paclitaxel may affect the occurrence of ferroptosis and control apoptosis in cancer cells. These findings not only serve as an exceptional tool for advancing our understanding of the ferroptosis response, but furthermore play a vital role in comprehending the biological characteristics of LDs in relation to ferroptosis.
Keyword ：
Bioimaging in cells and zebrafish Bioimaging in cells and zebrafish Ferroptosis Ferroptosis Fluorescent probe Fluorescent probe Lipid droplets Lipid droplets Paclitaxel Paclitaxel
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| GB/T 7714 | Wei, Di , Dai, Yingshu , Cao, Jing et al. A novel fluorescent probe for visualizing viscosity changes in lipid droplets during chemotherapy-induced ferroptosis [J]. | ANALYTICA CHIMICA ACTA , 2024 , 1299 . |
| MLA | Wei, Di et al. "A novel fluorescent probe for visualizing viscosity changes in lipid droplets during chemotherapy-induced ferroptosis" . | ANALYTICA CHIMICA ACTA 1299 (2024) . |
| APA | Wei, Di , Dai, Yingshu , Cao, Jing , Fu, Nanyan . A novel fluorescent probe for visualizing viscosity changes in lipid droplets during chemotherapy-induced ferroptosis . | ANALYTICA CHIMICA ACTA , 2024 , 1299 . |
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The polymorphic formation of G-quadruplex brings more attentions, because changes of formation sites affect many physiological processes, like telomere maintenance, transcription and DNA replication. These processes are highly susceptible to ROS-induced oxidative damage. In this work, bichromophoric cores of symmetric squaraine probe SQ linked with ether chain is conducive to the recognition of G-quadruplex, based on the mechanism of intra or intermolecular "aggregation-disaggregation". Several interaction behaviors, such as self-aggregation, binding affinity, stoichiometric ratio, were fully investigated via spectrum titration, circular dichroism, fluorescent intercalator displacement assay, and molecular docking. Furthermore, tracking G-quadruplex distribution in the cytoplasm was monitored by SQ during the oxidative stress enhancement. Interestingly, the Gquadruplex levels in the cytoplasm of cancer cells were slightly higher than that of normal cells to deal with oxidation-reduction imbalance. Overall, the lower detection limit of SQ for parallel G-quadruplex like pu27 is as low as 7.2 nM; and the complex of SQ and G-quadruplex will not change the topological structure of G-quadruplex. It has good sensitive and stability for parallel type of G-quadruplex. It is a potential tool for bioimaging of G-quadruplex in the cytoplasm.
Keyword ：
Bichromophoric squaraine Bichromophoric squaraine Cancer cell bioimaging Cancer cell bioimaging G-quadruplex detection G-quadruplex detection Near -infrared fluorescent probe Near -infrared fluorescent probe Oxidative stress model Oxidative stress model Supermolecular assembly Supermolecular assembly
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| GB/T 7714 | Rong, Lan , Cao, Jing , Dai, Yingshu et al. A bichromophoric squaraine based NIR fluorescent probe for G-quadruplex in living cells [J]. | DYES AND PIGMENTS , 2024 , 227 . |
| MLA | Rong, Lan et al. "A bichromophoric squaraine based NIR fluorescent probe for G-quadruplex in living cells" . | DYES AND PIGMENTS 227 (2024) . |
| APA | Rong, Lan , Cao, Jing , Dai, Yingshu , Chen, Wenxin , Fu, Nanyan . A bichromophoric squaraine based NIR fluorescent probe for G-quadruplex in living cells . | DYES AND PIGMENTS , 2024 , 227 . |
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The tertiary structures of HSA and BSA show a 76 % similarity, and the abnormal levels of HSA in body fluids can cause many diseases. Therefore, accurate quantification of HSA and effectively distinguishing HSA from BSA have significant application value in various fields. In this paper, a deep-red fluorescent probe, NITH, based on 1,8-naphthalimide, is demonstrated as a potential tool for accurately quantifying HSA and distinguishing HSA from BSA. The probe not only exhibits large stokes shift (100 nm) and low detection limit (4.61 mu g/L, 0.0692 nM), but also effectively detects HSA by entering its hydrophobic cavity and emitting red fluorescence. Furthermore, NITH is capable of tracking the distribution levels of HSA within the cells through endogenous and exogenous cellular imaging. The application of NITH spans various environments such as cells, zebrafish, urine, and test strips, solidifying it as an effective tool for HSA detection.
Keyword ：
Cell imaging Cell imaging Fluorescence probe Fluorescence probe HSA HSA Naphthalimide Naphthalimide TICT effect TICT effect
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| GB/T 7714 | Dai, Yingshu , Gong, Jiajia , Cao, Jing et al. A deep-red fluorescent probe based on naphthalimide for discrimination of HSA from BSA and tracking HSA by bioimaging [J]. | DYES AND PIGMENTS , 2023 , 222 . |
| MLA | Dai, Yingshu et al. "A deep-red fluorescent probe based on naphthalimide for discrimination of HSA from BSA and tracking HSA by bioimaging" . | DYES AND PIGMENTS 222 (2023) . |
| APA | Dai, Yingshu , Gong, Jiajia , Cao, Jing , Chen, Wenxin , Fu, Nanyan . A deep-red fluorescent probe based on naphthalimide for discrimination of HSA from BSA and tracking HSA by bioimaging . | DYES AND PIGMENTS , 2023 , 222 . |
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Human serum albumin (HSA) and hydrazine (N2H4) are known biomarkers and damage agents of liver function activity, respectively. However, the mechanism of association between HSA and N2H4 in the liver remains unexplored. Herein, we report a naphthalimide-based smart fluorescent probe NI-2 for the N2H4 mediated cascade detection of HSA (N2H4 boolean AND HSA). Results showed that the levulinate recognition group on NI-2 is ammonolyzed within seconds in response to N2H4, releasing the compound NI-OH, triggering a hypsochromic shift of the emission to 400 nm; while with the coexistence of HSA, the entry of NI-OH into the hydrophobic cavity of HSA, resulting a bathochromic emission shift to 670 nm. We have further revealed the reaction mechanism of NI-2 cascade reacting with N2H4 boolean AND HSA through HRMS, replacement experiment and molecular docking method. NI-2 has been successfully applied in detecting N2H4 boolean AND HSA in human urine quantitatively and N2H4 in water samples or plants. A qualitative test paper strip model for quick response of N2H4 and N2H4 boolean AND HSA has also been established. Moreover, NI-2 can be applied in bioimaging of HepG2 cells and zebrafish, indicating that NI-2 can be a potential tool for the study of liver damage.
Keyword ：
Bioimaging in cells and zebrafish Bioimaging in cells and zebrafish Cascade reaction Cascade reaction Human serum albumin and hydrazine Human serum albumin and hydrazine Paper strip Paper strip Smartfluorescent probe Smartfluorescent probe
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| GB/T 7714 | Ke, Yue , Wei, Di , Lu, Ziyao et al. A smart probe for multi-analyte signaling: Cascade detection of HSA mediated by N2H4 [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2023 , 395 . |
| MLA | Ke, Yue et al. "A smart probe for multi-analyte signaling: Cascade detection of HSA mediated by N2H4" . | SENSORS AND ACTUATORS B-CHEMICAL 395 (2023) . |
| APA | Ke, Yue , Wei, Di , Lu, Ziyao , Cao, Jing , Liu, Jianyong , Fu, Nanyan . A smart probe for multi-analyte signaling: Cascade detection of HSA mediated by N2H4 . | SENSORS AND ACTUATORS B-CHEMICAL , 2023 , 395 . |
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Human serum albumin (HSA) plays a pivotal role in various physiological processes of humans, and is generally considered to be one of the early signs of many diseases. Although dysfunction of intracellular lysosome is accompanied in those diseases, the regulation mechanism of HSA in lysosomes still need to be explored. In this work, we report a novel near-infrared naphthalimide probe NI-1 that specifically detects HSA in intracellular lysosomes with the "turn-on" fluorescent sensing modes. In the cell, the N-containing malononitrile group of NI-1 could bind to the lysosome. Moreover, NI-1 can specifically enter the site II hydrophobic cavity of HSA in lysosome. Due to the binding force between NI-1 and HSA, strong steric hindrance and the hydrophobic pocket inside HSA inhibit the twisted internal charge transfer (TICT) effect in the probe itself. Therefore, NI-1 emits strong red fluorescence. More importantly, NI-1 can effectively localize bioimaging of exogenous and endogenous HSA in lysosome. In addition, the novel probe NI-1 achieved a much high selectivity for HSA over bovine serum albumin (BSA), and the interaction mechanism between probe NI-1 and HSA or BSA site II was explained for the first time through molecular docking methods. These results indicate that the probe NI-1 has great potential in exploring further function of HSA for pharmacy and medicine.
Keyword ：
Cell imaging Cell imaging Naphthalimide Naphthalimide Near-infrared fluorescent probe Near-infrared fluorescent probe Recognition of HSA from BSA Recognition of HSA from BSA Targeted lysosome Targeted lysosome
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| GB/T 7714 | Ke, Yue , Cao, Jing , Gong, Jiajia et al. A near-infrared naphthalimide fluorescent probe for targeting the lysosomes of liver cancer cells and specifically selecting HSA [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2022 , 352 . |
| MLA | Ke, Yue et al. "A near-infrared naphthalimide fluorescent probe for targeting the lysosomes of liver cancer cells and specifically selecting HSA" . | SENSORS AND ACTUATORS B-CHEMICAL 352 (2022) . |
| APA | Ke, Yue , Cao, Jing , Gong, Jiajia , Fu, Nanyan . A near-infrared naphthalimide fluorescent probe for targeting the lysosomes of liver cancer cells and specifically selecting HSA . | SENSORS AND ACTUATORS B-CHEMICAL , 2022 , 352 . |
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Mercury (Hg) is an exceedingly toxic heavy metal which leads to grievous nonbiodegradable contamination and human health threat. Thus, developing a practical, quick, effective and labor-saving method for detecting Hg2+ is of great significance. In this study, we rationally design two novel near-infrared (NIR) monothiosquaraine-based probes MTSQ-1 and MTSQ-2 for tracking and bioimaging of Hg2+ with the mercury-desulfurization strategy. MTSQ-1 and MTSQ-2 show ultrahigh sensitivity, superb selectivity and rapid response for spotting of Hg2+ in vitro. We find that it is the intramolecular hydrogen bond between the carbonyl oxygen of the squaraine core and the ortho-hydroxyl substituent of the anilinyl moiety that promotes the desulfurization of the probes, inducing enhanced fluorescence emission. Related sensing mechanism has been fully discussed through experimental methods and theoretical calculations. Meanwhile, MTSQ-1 has been used in detection of Hg2+ in river samples, and MTSQ-2 encapsulated in beta-CD possesses good ability for imaging of Hg2+ in HeLa cells with high signal-tobackground ratio.
Keyword ：
Fluorescent probe Fluorescent probe Hg 2+detection Hg 2+detection High contrast bioimaging High contrast bioimaging Hydrogen bond promoted desulfurization Hydrogen bond promoted desulfurization Monothiosquaraine Monothiosquaraine
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| GB/T 7714 | Wang, Guimei , Xu, Wenjian , Liu, Yunfan et al. Ultrasensitive detection and high-contrast bioimaging of Hg2+ using monothiosquaraine-based fluorescent probe via hydrogen bond promoted desulfurization [J]. | MICROCHEMICAL JOURNAL , 2022 , 179 . |
| MLA | Wang, Guimei et al. "Ultrasensitive detection and high-contrast bioimaging of Hg2+ using monothiosquaraine-based fluorescent probe via hydrogen bond promoted desulfurization" . | MICROCHEMICAL JOURNAL 179 (2022) . |
| APA | Wang, Guimei , Xu, Wenjian , Liu, Yunfan , Fu, Nanyan . Ultrasensitive detection and high-contrast bioimaging of Hg2+ using monothiosquaraine-based fluorescent probe via hydrogen bond promoted desulfurization . | MICROCHEMICAL JOURNAL , 2022 , 179 . |
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Herein, we designed the tyrosinase specific sensing probe NITYO with recognition unit, 3-hydroxy benzyloxy, that also regarded as an electron-rich group that quenches the naphthalimide core by PET effect. When tyrosinase exists and catalyzes the secondary oxidation of NITYO, the fluorescence emission goes red shift with "turn-on" signal. We hypothesized and confirmed these results through comprehensive analysis such as molecular orbital analysis, molecular docking and HRMS. To sum up, we achieve the tyrosinase detection by NITYO with highly sensitivity and selectivity. It can be used in food samples and in vivo bioimaging. Besides, NITYO performs superb linear fitting and lower detection limit (0.33 U/mL) within the range of 10-400 U/mL.
Keyword ：
3-Hydroxy benzyloxy 3-Hydroxy benzyloxy Fluorescent probe Fluorescent probe Naphthalimide Naphthalimide Tyrosinase sensing Tyrosinase sensing Zebrafish bioimaging Zebrafish bioimaging
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| GB/T 7714 | Cao, Jing , Gong, Jiajia , Fu, Nanyan . A 1,8-naphthalimide based fluorescent probe for sensing tyrosinase in zebrafish [J]. | MICROCHEMICAL JOURNAL , 2021 , 173 . |
| MLA | Cao, Jing et al. "A 1,8-naphthalimide based fluorescent probe for sensing tyrosinase in zebrafish" . | MICROCHEMICAL JOURNAL 173 (2021) . |
| APA | Cao, Jing , Gong, Jiajia , Fu, Nanyan . A 1,8-naphthalimide based fluorescent probe for sensing tyrosinase in zebrafish . | MICROCHEMICAL JOURNAL , 2021 , 173 . |
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In this work, we rationally design a new type of squaraine dye SQ, modified with the dicyanovinyl motif that can specifically detect DQ (Diquat) by virtue of aggregation-disaggregation mechanism and electrostatic interaction between DQ and SQ. It undergoes H-aggregation in aqueous solution, resulting in fluorescence quenching. After the addition of DQ, the dicyanovinyl group on the probe reacts with DQ to deagglomerate so that the fluorescence is enhanced, tracing DQ in the environment with high sensitivity (LOD = 4.9 x 10(-7) M), selectivity and good stability. In addition, the actual sample spike recovery experiment and the confocal fluorescence imaging experiment of DQ in zebrafish also confirmed the detection method. At present, the "turn-on" type fluorescence probe for detecting DQ by using near-infrared squaraine dye has not been reported. The application of SQ provides a new strategy for the quantification of DQ.
Keyword ：
Aggregation-disaggregation Aggregation-disaggregation Dicyanovinyl-modified squaraine Dicyanovinyl-modified squaraine Diquat Diquat Electrostatic interaction Electrostatic interaction Near-infrared fluorescent probe Near-infrared fluorescent probe Zebrafish imaging Zebrafish imaging
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| GB/T 7714 | Jiang, Xiaoxue , Rong, Lan , Cao, Jing et al. Near-infrared fluorescent probe for tracing diquat in aqueous solutions and bioimaging in vivo [J]. | DYES AND PIGMENTS , 2021 , 191 . |
| MLA | Jiang, Xiaoxue et al. "Near-infrared fluorescent probe for tracing diquat in aqueous solutions and bioimaging in vivo" . | DYES AND PIGMENTS 191 (2021) . |
| APA | Jiang, Xiaoxue , Rong, Lan , Cao, Jing , Fu, Nanyan . Near-infrared fluorescent probe for tracing diquat in aqueous solutions and bioimaging in vivo . | DYES AND PIGMENTS , 2021 , 191 . |
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