Two　new　axially　disubstituted　silicon(W)　phthalocyanines　1　and　2　have　been　synthesized　by　treating　silicon　phthalocyanine　dichloride　with　1-adamantanemethanol　or　1-adamamtaneethanol,　respectively.　The　crystal　structure　of　compound　2　has　been　characterized　by　X-ray　diffraction　analysis.　Both　compounds　are　efficient　singlet-oxygen　generator　with　a　quantum　yield　of　0.40-0.43.　With　two　rigid　bulky　adamantane　moieties　at　the　axial　positions,　these　phthalocyanines　not　only　are　essentially　non-aggregated　in　common　solvents,　but　also　exhibit　a　high　photostability.　They　are　about　100　times　more　stable　than　zinc　phthalocyanine　under　the　same　irradiation　conditions.　With　the　goal　of　enhancing　the　bio-compatibilities,　interactions　and　conjugations　of　these　two　compounds　with　bovine　serum　albumin　have　also　been　investigated.　(C)　2010　Elsevier　Ltd.　All　rights　reserved.