This　paper　presents　an　investigation　of　the　influence　of　pile-soil-structure　interaction　(PSSI)　on　the　vibration　control　of　adjacent　buildings　with　pile　foundations.　With　the　initial　assumption　that　adjacent　buildings　are　linked　by　the　control　actuator　of　an　ideal　hydraulic　servo-system,　based　on　the　Penzien　model,　the　calculation　model　for　adjacent　structures　with　piled　foundations　considering　PSSI　is　established.　The　motion　and　control　equations　of　adjacent　structures　are　then　derived,　and　the　influences　of　PSSI　on　vibration　control　of　adjacent　buildings　analyzed.　Finally,　the　influences　of　soil　and　structural　parameters　on　structural　vibration　control　are　investigated.　The　results　show　that　the　PSSI　has　an　obvious　influence　on　the　response　of　adjacent　structures,　but　little　obvious　influence　on　the　change　in　control　force.　However,　the　soil　and　structural　parameters,　such　as　shear-wave　velocity　and　pile　stiffness,　play　a　significant　role　in　the　control　process.