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Abstract：
The common drawbacks of current colorimetric sensors using gold nanoparticle aggregation is its relatively low sensitivity and narrow dynamic range, which restrict their application in real sample analysis when competing with other analytical techniques such as fluorescence and chemiluminescence. In this article, we demonstrate a novel strategy to construct colorimetric sensors based on gold nanoparticle aggregation. Unlike the conventional colorimetric sensors which cause the formation of large nanoparticle aggregates, in our strategy, dimers are selectively formed upon target binding, which results in significantly improved long-term stability and a more than 2 orders of magnitude wider dynamic range of detection than that of the conventional colorimetric sensors. In addition, a strategy to minimize the interparticle gap through the formation of a Y-shaped DNA duplex enables to increase the limit of detection by 10 000 times. The analytical figures of merit of the proposed sensor are comparable to those of the fluorescence-based sensors.
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN： 0002-7863
Year： 2013
Issue： 33
Volume： 135
Page： 12338-12345
1 1 . 4 4 4
JCR@2013
1 4 . 5 0 0
JCR@2023
ESI Discipline： CHEMISTRY;
JCR Journal Grade：1
CAS Journal Grade：1
Cited Count：
SCOPUS Cited Count：
ESI Highly Cited Papers on the List： 37 Unfold All
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30 Days PV： 0
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