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Abstract：
Multifunctional nanocomposites have the potential to integrate sensing, diagnostic, and therapeutic functions into a single nanostructure. Herein, we synthesize Fe3O4@polydopamine core shell nanocomposites (Fe3O4@PDA NCs) through an in situ self-polymerization method. Dopamine, a melanin-like mimic of mussel adhesive proteins, can self-polymerize to form surface-adherent polydopamine (PDA) films onto a wide range of materials including Fe3O4 nanoparticles used here. In such nanocomposites, PDA provides a number of advantages, such as near-infrared absorption, high fluorescence quenching efficiency, and a surface for further functionalization with biomolecules. We demonstrate the ability of the Fe3O4@PDA NCs to act as theranostic agents for intracellular mRNA detection and multimodal imaging-guided photothermal therapy. This work would stimulate interest in the use of PDA as a useful material to construct multifunctional nanocomposites for biomedical applications.
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ACS NANO
ISSN： 1936-0851
Year： 2014
Issue： 4
Volume： 8
Page： 3876-3883
1 2 . 8 8 1
JCR@2014
1 5 . 8 0 0
JCR@2023
ESI Discipline： MATERIALS SCIENCE;
ESI HC Threshold：355
JCR Journal Grade：1
CAS Journal Grade：1
Cited Count：
WoS CC Cited Count： 587
SCOPUS Cited Count： 605
ESI Highly Cited Papers on the List： 44 Unfold All
WanFang Cited Count：
Chinese Cited Count：
30 Days PV： 2
Affiliated Colleges：
