An　in　situ　hydrothermal　route　is　developed　for　fabricating　rutile　TiO2　mesocrystals/reduced　graphene　oxide　nanosheets　(TGR)　hybrids　in　the　presence　of　dodecylbenzenesulphonic　acid　(ADBS).　These　rutile　TiO2　mesocrystals　with　a　Wulff　shape　are　composed　of　ultra-tiny　rod-like　subunits　with　the　same　oriented　direction　and　closely　wrapped　by　the　nanosheets　of　reduced　graphene　oxide　(RGO).　It　is　found　that　ADBS　played　a　key　role　for　the　formation　of　mesocrystals　during　the　self-assembly　process,　which　pillared　the　graphene　oxide　(GO)　nanosheets　and　involved　the　aggregation　of　the　mesocrystal　subunits.　Furthermore,　the　TGR　hybrids　are　used　as　an　anode　material　and　exhibited　a　large　capacity　over　150　mAh　g(-1)　at　20　C　after　1000　cycles,　and　high　rate　capability　up　to　40　C.　These　high　performance　characteristics　may　be　due　to　the　intrinsic　characteristics　of　rutile　TiO2　mesocrystals　constructed　from　ultra-tiny　subunits　and　hybridized　with　super　conductive　RGO　nanosheets.