A　heterometallic　metal-organic　framework,　AgIn(nicotinate)(4)center　dot　1.5DMF,　was　obtained　from　the　reaction　of　nicotinic　acid,　AgNO3　and　In(NO3)(3)　in　DMF.　The　complex　was　characterized　by　elemental　analysis,　infrared　spectrum,　thermogyavimetric　analysis,　powder　X-ray　diffraction　and　single-crystal　X-ray　diffraction.　Crystal　data　are:　C28.5H26.5N5.5O9.5AgIn,　orthorhombic　space　group　I222,　a　=　10.775(15),　b　=　11.939(18),　c　=　13.93(2)　angstrom,　V=　1792(5)　angstrom(3),　Z　=　2,　D-c　=　1.521　mg/m(3),　mu　=　1.244　mm(-1),　F(000)　=　816,　the　final　R　=　0.0672　and　wR　=　0.1812　for　1912　observed　reflections　with　I　＞　2　sigma(I).　Single-crystal　X-ray　structure　analysis　reveals　that　nicotinate　bridges　In(III)　and　Ag(I)　through　carboxylate　chelating　with　In(III)　and　pyridyl　nitrogen　atom　coordinating　to　Ag(I),　generating　a　new　2D　network　consisting　of　tetrahedral　building　units　of　[AgN4](+)　and　[In(COO)(4)](-).