Trifluoromethylation of (hetero)aryl iodides and bromides with copper(I) chlorodifluoroacetate complexes - Details

author：

Lin, Xiaoxi (Lin, Xiaoxi.) ^[1] | Li, Zhengyu (Li, Zhengyu.) ^[2] | Han, Xiaoyan (Han, Xiaoyan.) ^[3] | Weng, Zhiqiang (Weng, Zhiqiang.) ^[4]

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Abstract：

A　new　copper-mediated　trifluoromethylation　reaction　using　copper(I)　chlorodifluoroacetate　complexes　as　reagents　is　reported.　The　complex　[L2Cu][O2CCF2Cl]　(L　=　bpy,　dmbpy,　phen)　reacted　with　(hetero)aryl　iodides　and　bromides　in　the　presence　of　CsF　in　DMF　at　75　degrees　C　to　afford　the　trifluoromethylarenes　in　good　to　excellent　yields.　High　compatibility　with　various　chemical　functions　or　(hetero)　cycles　was　also　observed　in　the　reaction.　A　reaction　mechanism　involving　a　difluorocarbene　intermediate,　along　with　a　subsequent　formation　of　a　-CF3　anion　was　proposed.

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Community：

[ 1 ] [Lin, Xiaoxi]Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350108, Fujian, Peoples R China
[ 2 ] [Li, Zhengyu]Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350108, Fujian, Peoples R China
[ 3 ] [Weng, Zhiqiang]Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350108, Fujian, Peoples R China
[ 4 ] [Han, Xiaoyan]Soochow Univ, Testing & Anal Ctr, Suzhou 215123, Peoples R China
[ 5 ] [Weng, Zhiqiang]Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China

Reprint 's Address：

翁志强
[Weng, Zhiqiang]Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350108, Fujian, Peoples R China;;[Han, Xiaoyan]Soochow Univ, Testing & Anal Ctr, Suzhou 215123, Peoples R China;;[Weng, Zhiqiang]Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China

Email：

hanxiaoyan@suda.edu.cn |
zweng@fzu.edu.cn

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Version：

Trifluoromethylation of (hetero)aryl iodides and bromides with copper(i) chlorodifluoroacetate complexes
2016，RSC Advances
Trifluoromethylation of (hetero)aryl iodides and bromides with copper(i) chlorodifluoroacetate complexes
2016，RSC Advances

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RSC ADVANCES

ISSN： 2046-2069

Year： 2016

Issue： 79

Volume： 6

Page： 75465-75469

3 . 1 0 8

JCR@2016

3 . 9 0 0

JCR@2023

ESI Discipline： CHEMISTRY;

ESI HC Threshold：235

JCR Journal Grade：2

CAS Journal Grade：3

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 20

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 2

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