Trifluoromethylation of (hetero)aryl iodides and bromides with copper(i) chlorodifluoroacetate complexes - Details

author：

Lin, X. (Lin, X..) ^[1] | Li, Z. (Li, Z..) ^[2] | Han, X. (Han, X..) ^[3] | Weng, Z. (Weng, Z..) ^[4]

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Abstract：

A　new　copper-mediated　trifluoromethylation　reaction　using　copper(i)　chlorodifluoroacetate　complexes　as　reagents　is　reported.　The　complex　[L2Cu][O2CCF2Cl]　(L　=　bpy,　dmbpy,　phen)　reacted　with　(hetero)aryl　iodides　and　bromides　in　the　presence　of　CsF　in　DMF　at　75　°C　to　afford　the　trifluoromethylarenes　in　good　to　excellent　yields.　High　compatibility　with　various　chemical　functions　or　(hetero)cycles　was　also　observed　in　the　reaction.　A　reaction　mechanism　involving　a　difluorocarbene　intermediate,　along　with　a　subsequent　formation　of　a　-CF3　anion　was　proposed.　©　The　Royal　Society　of　Chemistry　2016.

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[ 1 ] [Lin, X.]State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fujian, 350108, China
[ 2 ] [Li, Z.]State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fujian, 350108, China
[ 3 ] [Han, X.]Testing and Analysis Center, Soochow University, Suzhou, 215123, China
[ 4 ] [Weng, Z.]State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fujian, 350108, China
[ 5 ] [Weng, Z.]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China

Reprint 's Address：

[Han, X.]Testing and Analysis Center, Soochow UniversityChina

Email：

hanxiaoyan@suda.edu.cn

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Source ：

RSC Advances

ISSN： 2046-2069

Year： 2016

Issue： 79

Volume： 6

Page： 75465-75469

3 . 1 0 8

JCR@2016

3 . 9 0 0

JCR@2023

ESI HC Threshold：235

JCR Journal Grade：2

CAS Journal Grade：3

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 1

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